Chercheur post-doctoral, Livraison d’ARN médiée par des anticorps, États-Unis

USA
نشرت 3 أشهر منذ

Chez Lilly, nous unissons l’attention à la découverte pour améliorer la vie des gens du monde entier. Nous sommes un leader mondial des soins de santé dont le siège est à Indianapolis, Indiana. Nos 35 000 employés à travers le monde travaillent pour découvrir et apporter des médicaments qui changent la vie à ceux qui en ont besoin, améliorer la compréhension et la gestion de la maladie et redonner à nos communautés par le biais de la philanthropie et du bénévolat. Nous donnons le meilleur de nous-mêmes à notre travail et nous accordons la priorité aux personnes. Nous recherchons des personnes déterminées à améliorer la vie des gens du monde entier.

Voulez-vous faire une différence significative en contribuant à une nouvelle génération de molécules biothérapeutiques qui pourraient aider à résoudre des besoins médicaux non satisfaits dans un large éventail de domaines pathologiques ? Nous offrons un environnement de recherche de premier ordre et un groupe de biotechnologie à la pointe de l’industrie qui a fait ses preuves dans le développement de médicaments ayant un impact sur la vie des patients. C’est une opportunité fantastique de faire partie de notre communauté scientifique de recherche postdoctorale!

Nous recherchons un chercheur postdoctoral travailleur doté de compétences de recherche exceptionnelles pour contribuer à des projets de recherche très visibles à Lilly. Ce rôle se concentrera sur le développement d’une nouvelle classe de bioconjugués anticorps-oligonucléotide. Si vous êtes un scientifique multidisciplinaire passionné, envisagez de postuler à ce poste passionnant !

Concrètement, vous pourrez :

    • Build innovative molecular systems and novel approaches for antibody-mediated cytoplasmic delivery of siRNA and provide insight into intracellular trafficking and organelle escape
    • Use and characterize a new generation of antibody-oligonucleotide conjugates to understand and control subcellular trafficking
    • Develop molecular strategies to improve endosomal escape and productive siRNA delivery
    • Provide foundational knowledge for Lilly’s emerging antibody-oligonucleotide conjugate platform, whilst also supporting other antibody bioconjugate platforms
    • Present findings at conferences and publish in high quality peer-reviewed journals

This role will be embedded in Lilly’s Medicines Innovation Hub (MIH), which serves as a ground breaking scientific unit working across all disease areas to identify and develop quality targets, hits, leads, and drug candidates. We’re looking for a self-directed and highly motivated individual who wants to learn new techniques while continually pursuing research and publication goals.

Basic Qualifications

PhD in a life science related field

Additional Skills/Preferences

    • Experience in (or knowledge of) intracellular delivery and trafficking of proteins and oligonucleotides; Oligonucleotide research experience
    • Adept at cell culture, flow cytometry, confocal microscopy, cell engineering, and data analysis
    • Experience with protein/antibody engineering and purification, as well as biochemical characterization
    • Experience in protein/antibody conjugation and analytical characterization techniques including chromatography
    • Experience with mammalian cell culture and subcellular trafficking
    • Experience with molecular biology (plasmid design, transfection methods, troubleshooting) and protein-level analysis
    • Glycobiology knowledge
    • Outstanding communicator (oral and written) with a strong publication record and experience presenting at international conferences
    • Proficient in data analysis and reporting (GraphPad Prism, Excel, PowerPoint, Photoshop, Spotfire, etc.)

Additional Information

This position is not permanent. It is for a fixed duration of two years with potential to extend to maximum of up to 4 years.

About Eli Lilly’s Postdoctoral Scientist Program

When it comes to research and development, our goal is to discover and deliver innovative medicines that make life better for people around the world. It’s challenging, expensive and often filled with failure. But even when we fail, we advance medical science and understanding by learning more about diseases, biology and chemistry – ultimately bringing new solutions one step closer to reality.

Over the course of our history, we have shed light on some of the toughest health care problems known to man – diabetes, heart disease, infectious diseases, neuroscience disorders, cancer and more. We could not pursue this without our research and development team. Postdoctoral scientists help us continue this pursuit. During your experience you will get:

    • Top industry research experience
    • Mentoring by some of Lilly’s top scientists
    • Training and coaching opportunities to further your development
    • Collaboration and networking across other postdoctoral scientists and researchers

Eli Lilly and Company, Lilly USALLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( Lilly_Recruiting_Compliance@lists.lilly.com ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and help our company develop talented individuals for future leadership roles. Our current groups include: Africa, Middle East, Central Asia Network, African American Network, Chinese Culture Network, Early Career Professionals, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinos at Lilly, PRIDE (LGBTQ + Allies), Veterans Leadership Network, Women’s Network, Working and Living with Disabilities. Learn more about all of our groups.

Comme condition d’emploi chez Eli Lilly and Company et ses filiales aux États-Unis et à Porto Rico, vous devez être entièrement vacciné contre le COVID -19 et fournir une preuve de vaccination satisfaisante pour l’entreprise (sous réserve de la loi applicable).

#WeAreLilly

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تصنيف الوظيفةPost doc

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