Scholarship in Europe

Post doc scholarship in bioinformatics at Lund University, Sweden

The Molecular Pediatric Oncology lab, led by PI Daniel Bexell, is working with childhood cancer neuroblastoma. The overall aims are to unravel mechanisms leading to metastasis and treatment resistance of neuroblastoma, and to test compounds targeting aggressive neuroblastoma.

 

We have recently established and characterized multiple neuroblastoma orthotopic patient-derived xenografts (PDXs). These PDXs retain the genotype, phenotype, tumorigenic, and metastatic properties of the tumors from which they were derived, making them authentic models for studying and targeting neuroblastoma metastasis and resistance (Braekeveldt et al., Cancer Res, 2018). The lab recently used high-throughput drug screening, 3D tumor organoids and PDX models to demonstrate that KSP-inhibition is a promising strategy in neuroblastoma (Hansson et al., Science Transl Med, 2020).

 

We perform molecular and functional studies of primary and metastatic tumor cells, as well as in vitro and in vivo drug testing using 3D tumor organoids and PDXs as model systems. Methods include cell- and molecular biology techniques, 3D tumor cell culturing, RNA-sequencing, spatial transcriptomics, clonal evolution assays, in vitro and in vivo drug testing.

 

We are looking for a new post doc with bioinformatics experience to join our team. Focus will be on analysis of data generated in the different projects described above, with a special focus on bulk RNA-seq, scRNA seq analysis and spatial transcriptomics. The post-doc will lead and develop his/her own analyses and projects. The post-doc will also work in close collaboration with the rest of the team to apply various algorithms and bioinformatics tools to diverse types of bulk and single-cell generated data. The successful candidate will have the opportunity to use a computation-based approach to analyze omics data generated in the group as well as to use publicly available databases to generate testable hypothesis. Tasks also include scientific writing.

 

We offer an international research environment with the opportunity to develop as a researcher. We value a collaborative, curious, ambitious, and nonhierarchical culture with focus on improving the lives for children with cancer.

 

Qualifications required

1. The applicant should be able to conduct projects independently and critically

2. Broad experience of bioinformatics analyses

3. PhD in a relevant subject such as bioinformatics, computational biology, genomics or similar

4. Having demonstrated knowledge with data analyses on genomic and transcriptomic levels, with proficiency in scientific programming languages (eg. R)

5. Experience from single cell (sc)RNAseq and/or spatial transcriptomics is a strong merit

6. Experience with cancer research is also a merit

7. Excellent communication skills and be able to interact efficiently in a team

8. Personal suitability is very important

9. Excellent spoken and written English

 

The applicant should not have been employed by Lund University within the last two years in order to be able to receive a scholarship. PhD degree should not be more than three years old at the last day of applying,

 

Placement: Division of Translational Cancer Research, Medicon Village, Lund University, Lund, Sweden

Web: https://www.tcr.lu.se/research-groups/molecular-pediatric-oncology

Announcement: https://www.med.lu.se/intramed/stipendier_anslag_fraan_fakulteten/#item_150634

Ref No: V2022/1791

Duration: 24 months

Starting time: preliminary November 1st, 2022 (can be discussed)

Last day for applying: September 30th, 2022

 

For further information please contact:

Daniel Bexell

daniel.bexell@med.lu.se

 

Other

Lund University encourages both men and women to apply for the position.

 

Information regarding post doc scholarships at Lund University

The scholarship amounts to 29 000 SEK/month and is normally paid three months in advance.

The scholarship is a grant and therefore not subjected to tax deduction.

 

Application

Application stating the reference number V 2022/1791 and containing a CV, a personal letter, proof of dissertation and relevant documents should be addressed to: daniel.bexell@med.lu.se.

 

Last day of application is 2022-09-30

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