This is a full-time, fixed term (4 year) position on Crick terms and conditions of employment
Chemical Biology – Chemoproteomics
The successful candidate will be part of a dynamic, multi-disciplinary team working to develop a Systems Chemical Biology approach to biomedical research through combination of chemoproteomics, high-content screening, reactive fragments and cutting-edge genomics in disease relevant biological systems. Resulting full matrix datasets will be interrogated using bioinformatics and machine learning technologies to accelerate the selection of new drug targets. The candidate will be expected to lead their own projects. This is a multi-faceted project with a strongly interdisciplinary focus. The project will be co-supervised by Crick and GSK scientists and has considerable scope to evolve.
Scientific Computing and Crick-GSK LinkLabs
This Crick–GSK LinkLabs collaboration is aimed at developing a Systems Chemical Biology platform to enable simultaneous identification of disease-associated proteins and functional chemical probes. The project is funded by an EPSRC Prosperity Partnership award that brings together multiple research groups at the Crick and GSK to pioneer reactive fragments and high-content screening technologies in cells (https://www.crick.ac.uk/news/2021-04-02_francis-crick-institute-and-gsk-to-pioneer-reactive-fragment-screening-in-drug-discovery and https://www.crick.ac.uk/news/2019-02-08_benefits-of-moving-in-together ).
This is an exciting opportunity to join one of the world’s leading research institutes as part of the Crick-GSK LinkLabs collaboration at a crucial time in its evolution and play a definitive role in shaping it for the future. We seek a talented, highly motivated chemical biologist with experience in chemoproteomics and mass spectrometry.
The role will reside in Proteomics STP within the Francis Crick Institute, led by Mark Skehel, and will work closely with the Crick-GSK LinkLabs team, including chemists, biologists and ‘omics scientists, bioinformatians and machine learning engineers. The successful candidate will be responsible for i) driving the expansion of the ligandable proteome through chemoproteomics analysis of reactive fragment libraries and ii) chemoproteomics analysis of hits from phenotypic screens to generate insights into disease biology to identify targets, pathways and compounds offering therapeutic potential.
These include but are not limited to:
Drive the implementation of state-of-the-art mass spectrometric chemoproteomics techniques to profile reactive fragments in cells to identify fragment-protein interactions in across the proteome.
Optimise the data processing of raw chemoproteomics data to maximise the insights into fragment-protein interaction.
Contribute to the strategy for the Systems Chemical Biology Platform being developed within the GSK-Crick LinkLab partnership, in particular with respect to the deployment and interpretation of MS-chemoproteomics to guide reactive fragment library design and deconvolution of phenotypic screens.
Perform integrative analyses of large chemoproteomic data in the context of data from high-content ‘omics screens and phenotypic screens to maximise insights from probe the relationship between molecule, protein, gene and phenotype to interrogate biological systems in the context of disease biology.
Work closely with Crick and GSK researchers (e.g.chemistry, high-content screening, biology, data and machine learning) to guide experimental design and drive the interpretation of outcomes.
Analyse, assimilate, and communicate complex scientific data clearly and concisely to members of the team and the broader scientific community.
Key qualifications, experience and competencies
The post holder should embody and demonstrate our core Crick values: bold, imaginative, open, dynamic and collegial, in addition to the following:
First class or 2:1 degree in chemistry or biochemistry.
Completion of a PhD in the field of chemical biology, chemoproteomics or mass spectrometry.
A broad and deep knowledge of contemporary chemical biology techniques in relation to small molecule drug discovery, including with respect to target identification, validation, tractability and engagement
A track record of high productivity working across the chemistry-biology interface, supported by publications in peer-reviewed journals.
Able to work effectively without close supervision, working successfully and collaboratively in multidisciplinary teams.
Excellent communication skills, with the ability to build effective relationships at all levels and the ability to communicate technical concepts to a non-technical audience
Highly motivated, self-starter and committed to learning and personal improvement
Experience of knowledge in any of the following areas would be beneficial:
Qualifications, experience and competencies:
Experience of analysing large biological datasets to support biomedical sciences, in particular from ‘omics experiments (proteomics, genomics, metabolomics).
Knowledge of and experience with common bioinformatics databases, resources and tools, including pathway and network methods.
Chemistry awareness/familiarity with the following concepts: SMILES, InChI Keys, Tanimoto similarity, etc.
Find out what benefits the Crick has to offer:
For more information on our great pay and benefits package please click here: https://www.crick.ac.uk/careers-and-study/life-at-the-crick/pay-and-benefits
Equality, Diversity & Inclusion:
We welcome applications from all backgrounds. We are committed to providing equal employment opportunities, regardless of ethnicity, nationality, gender, sexual orientation, gender identity, religion, pregnancy, age, disability, or civil partnership, marital or family status. We particularly welcome applications from people who are Minority Ethnic as they are currently underrepresented in the Crick at this level.
Diversity is essential to excellence in scientific endeavour. It increases breadth and perspective, leading to more innovation and creativity. We want the Crick to be a place where everyone feels valued and where diversity is celebrated and seen as part of the foundation for our Institute’s success.
The Crick is committed to creating equality of opportunity and promoting diversity and inclusivity. We all share in the responsibility to actively promote dignity, respect, inclusivity and equal treatment and it is our aim to ensure that these principles are reflected and implemented in all strategies, policies and practices.
Read more on our website: https://www.crick.ac.uk/careers-and-study/life-at-the-crick/equality-diversity-and-inclusion
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