Laboratory of Prof. Jussi Taipale at the Medical Systems Biology group (https://www2.helsinki.fi/en/researchgroups/medical-systems-biology) at the Applied Tumour Genetic Program at University of Helsinki, Faculty of Medicine invites applications for the position of two postdoctoral researchers.
Our research group is part of the Academy of Finland’s Centre of Excellence in Tumour Genetics Research. The laboratory focuses on the study of transcriptional control of cell growth, using functional genomics and systems biology. Current lines of work include high-throughput determination of binding sites and binding specificities of human transcription factors, using this information to identify regulatory elements that control cell growth during normal development or in cancer.
Applicants with a doctoral degree and strong background in molecular biology/bioinformatics who are interested in working in an inter-disciplinary environment are particularly encouraged to apply. Applicant must be able to work independently and have good communication skills in English.
Two positions are available and the appointment will be for 3 years starting from 1st January 2023. Trial period of 6 months will be applied. The monthly gross salary will be appr. 3200-3500 € per month depending on the appointee’s qualifications and experience. In addition, University of Helsinki offers comprehensive services to its employees, including occupational health care and opportunities for professional development. Further information at www.helsinki.fi/en/about-us/careers.
Please submit your application as a single PDF file containing your CV (2 pages), a publication list including impact factors and two letters of reference at email@example.com
The deadline for applications is 23 October 2022.
Selected publications from Taipale lab:
Sahu et al. Sequence determinants of human gene regulatory elements. Nature Genetics, 2022, in press.
Sahu et al. Human cell transformation by combined lineage conversion and oncogene expression. Oncogene. 2021, Sept, 5533-5547.
Zhu et al. The interaction landscape between transcription factors and the nucleosome. Nature. 2018, Oct, 76-81.
Yin et al. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science, 2017, May 5;356(6337).
Turunen et al. (2014) Uterine Leiomyoma-Linked MED12 Mutations Disrupt Mediator-Associated CDK Activity. Cell Rep 7, 654–60.
Yan et al. (2013) Transcription factor binding in human cells occurs in dense clusters formed around cohesin anchor sites. Cell 154, 801-13.
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