You will participate in a structure-based drug design approach to combat the zoonotic risk imposed by poxviral reservoirs and human pathogenic poxvirus strains. To this end, we target the unique poxviral transcription machinery, which relies exclusively on virus-encoded proteins. As a basis, we recently reported the isolation and comprehensive structural investigation of this machinery in different phases of action. This enables the identification and design of small molecules that interfere with poxviral gene expression and their subsequent translation into antiviral pharmaceuticals.
The unexpected severity of the ongoing monkeypox outbreak underlines the timeliness of this project.
Our recent publications on the topic:
Grimm et al., Cell 179 (7): 1537-1550 (2019)
Hillen et al., Cell 179 (7): 1525-1536 (2019)
Grimm et al., Nat. Struct. Mol. Biol. 28 (10): 779-788 (2021)
Grimm et al., TIBS (2022)
You’re highly motivated and have a solid background in biochemistry and/or virology.
Good communication and teamwork skills and fluency in English are essential. The Postdoc position requires a PhD in life sciences.
The PhD Student position requires an M.Sc. in life sciences or equivalent for enrollment at Würzburg Graduate School of Life Sciences (GSLS). Experience in protein biochemistry, biophysics or structural biology is beneficial but not a strict prerequisite.
A highly stimulating international research environment in a well-equipped, modern lab at Würzburg University’s Biocenter, which provides diverse opportunities for collaboration.
For the PhD candidate, enrollment at Würzburg Graduate School of Life Sciences (GSLS) will provide a framework and structured education program.
Remuneration and benefits according to public service positions in Germany, including 30 days of paid leave and a salary of 100% TV-L E13 (Postdoc) or 65% TV-L E13 (PhD student).
Applicants with disabilities will be preferred in case of equivalent qualifications.
Please send your application package, which should include a statement of motivation, a detailed CV and the contact details of at least two references, as a single file PDF by e-mail to firstname.lastname@example.org.
Applications should be submitted by 9 October, 2022 latest and will be reviewed as they arrive.
For further information, please contact Utz Fischer (email@example.com, Tel.: +49 931-31 84029).
|Job Category||Doctorat, Post doc|