Three-year Postdoc position in organoid/spheroid systems and tumor glyco-regulation – Marseille, France

RESEARCH FIELD(S)

BIOLOGY

How cancer cells alter the glycosylation of cell surface proteins and how these modifications alter interactions between tumour cells and their environment: ECM, epithelial cells and immune system. To study these interactions, we will develop organoids and high-throughput 3D imaging. The project goal is to better understand how cancer cells destroy normal tissues and inhibit immune cells to allow for tumour growth.

Nguyen AT, Chia J, Ros M, Hui KM, Saltel F, Bard F. Organelle Specific O-Glycosylation Drives MMP14 Activation, Tumor Growth, and Metastasis. Cancer Cell. 2017 Nov 13;32(5):639–653.e6. PMID: 29136507

Ros M, Nguyen AT, Chia J, Le Tran S, Le Guezennec X, McDowall R, Vakhrushev S, Clausen H, Humphries MJ, Saltel F, Bard FA. ER-resident oxidoreductases are glycosylated and trafficked to the cell surface to promote matrix degradation by tumour cells. Nat Cell Biol. 2020 Nov;22(11):1371–1381. PMID: 33077910

JOB DESCRIPTION 

The group “Glycosylation, Cellular INterfaces and Therapies” (GLYNTERA) is newly formed and funded by an Excellence Chair from Amidex and the ARC grant “International Leaders in Oncology”. The position will be funded at a competitive level.

QUALIFICATIONS/SKILLS/EDUCATION & RESEARCH REQUIREMENTS

• PhD in Life Sciences
• Good mastery of biomedical lab biology techniques (Western Blot, cell culture)
• Solid expertise in confocal microscopy and image analysis
• Solid expertise in spheroid and/or organoid related techniques
• Aptitude to develop protocols and perform data analysis
• Enthusiastic about science and driven to succeed
• Good English written and oral skills

APPLICATION DEADLINE: 

15 April 2022

STARTING DATE: 

15 April 2022

JOB LOCATION : 

The CRCM is located in the Institut Paoli Calmettes campus in Marseille

REQUESTED DOCUMENTS OF APPLICATION :

CV, motivation e-mail and 2 recommendation letters

CONTACT TO APPLY: 

frederic.bard@inserm.com