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Postdoctoral fellow positions are available in the laboratory of Dr. Xi Chen, Assistant Professor and CPRIT scholar in cancer research at the Department of Molecular and Cellular Biology, Lester and Sue Smith Breast Center and NCI designated Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine. The Chen lab studies the function and mechanism of protein quality control machinery in cancer immunology, metastasis, and therapy resistance. Our long-term goals is to elucidate the significance and mechanisms of proteostasis in cancer progression, metastasis, interaction with immune system, and therapy resistance, and developing mechanism-based novel therapies to overcome therapy resistance and transform cancer to a manageable chronic disease. Our recent study revealed an unprecedented role of the IRE1a/XBP1 branch of the Endoplasmic Reticulum (ER) stress response in mediating tumor homeostasis and therapy resistance. We have developed a mechanism-based combination therapy with the IRE1a inhibitor and docetaxel that completely eradicated the primary breast tumors, prevented recurrence and triggered robust anti-tumor immunity. This study has led to a recent clinical trial. The highly interdisciplinary and collaborative environment of our group provides unique career development opportunities for the postdoc trainees. Please refer to our representative publications for details: [Nature Cell Biology (2020, accepted); JCI (PMID: 29480818); Nature (PMID: 24670641); Cell (PMID: 18555785); Nature Immunology (PMID: 31086333): Nature Immunology (PMID: 21151104); Nature Cell Biology (PMID:21170031); Nature Immunology (PMID: 20351694); Nature Genetics (PMID: 16518401)].
Qualifications • A Ph.D. (or equivalent) in biomedical sciences, highly motivated and career-oriented. • Strong background and working knowledge in immunology and cancer biology. • Expertise in flow cytometry and animal models is strongly preferred.
Please email CV to chenlab.bcm@gmail.com if interested.
