(Valid from 26/10/2023 to 31/01/2024)
Language: English (UK)
Organisation data: LCSB
Job Number: UOL06068
Contract Type: Fixed Term Contract
Duration 12 Month
Schedule Type: Full Time
Work Hours 40.0 Hours per Week
Expected Start Date: 01/12/2023
Job (internal): Postdoctoral researcher
The Luxembourg Centre for Systems Biomedicine (LCSB) is an interdisciplinary research centre of the University of Luxembourg. We conduct fundamental and translational research in the field of Systems Biology and Biomedicine – in the lab, in the clinic and in silico. We focus on neurodegenerative processes and are especially interested in Alzheimer’s and Parkinson’s disease and their contributing factors.
The LCSB recruits talented scientists from various disciplines: computer scientists, mathematicians, biologists, chemists, engineers, physicists and clinicians from more than 50 countries currently work at the LCSB. We excel because we are truly interdisciplinary and together we contribute to science and society.
We are looking for a highly motivated and dynamic researcher for a 1-year post-doctoral position in the Translational Neuroscience team headed by Prof. Rejko KRÜGER, under the joint supervision of the head of the Group and Dr. Giuseppe Arena. Preference will be given to candidates with a strong background in Functional Neurogenomics and Cellular and Molecular Neurosciences, and expertise/technical skills in induced pluripotent stem cell-(iPSC)-derived neuronal cultures and cellular phenotyping. The aim of this project is to investigate molecular determinants linking distinct mutations in the mitochondrial outer membrane protein Miro1, to the molecular and cellular phenotypes underlying neurodegeneration.
The Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg is a highly dynamic, multilingual and international working environment at campus Belval. The Translational Neuroscience team’s focus lies in the identification of new biomarkers and therapeutic targets for PD, aimed at bridging the gap between fundamental research and clinical research by embedding the “from bench to bed” research approach. Fundamental research focuses on iPSC-derived neuronal models to elucidate the molecular and cellular alterations contributing to neurodegeneration in familial and idiopathic forms of PD, Dementia with Lewy bodies, atypical parkinsonism, and amyotrophic lateral sclerosis (ALS). Newly-discovered molecular targets and disease-associated cellular phenotypes are used as readouts in drug screening approaches, in order to identify molecules that, after in vitro and in vivo validation, could be potentially used in future intelligent clinical trials.
Tasks / Activities
We are offering a one-year postdoc position with an option for prolongation in the form of a full-time employment at the University of Luxembourg. The project aims at dissecting the contribution of pathogenic variants in the RHOT1 gene – encoding the mitochondrial calcium sensor Miro1 – to the pathogenesis of Parkinson’s disease. The candidate will be involved in experimental work aimed at investigating the molecular and functional consequences of impaired Miro1 activity, including analysis of mitochondrial function, metabolic reprogramming, intracellular signaling pathways (e.g., calcium signaling) and neuronal activity/viability. Both in vitro (i.e., primary skin fibroblasts, iPSC-derived neuronal cells) and in vivo (i.e., knock-in mice carrying the Miro1 mutation) models will be used in this project.
What we expect from you…
We are looking for a highly motivated and enthusiastic scientist with the following competencies and experience:
Essential experience and skills:
- You have a PhD in Neurosciences, Cell Biology or related fields
- You are highly experienced in working with cell-based models and you master the main cellular/molecular biology and biochemistry techniques, especially experimental approaches for assessing mitochondrial function and dynamics would be an asset
- You have a proven ability to conduct research independently and to reach the project objectives (at least one publication as first author in peer-reviewed international journals)
- You have proficient communication and organizational skills, and ability to work in team
- You have an excellent knowledge of written and spoken English
Desirable experience and skills:
- Experience in stem cell-based (especially iPSC-derived neurons) and mouse models are considered to be an advantage
- Ability to conceive innovative research proposals and experience with grant writing
Here’s what awaits you at the LCSB…
- Excellent work environment with state-of-the-art infrastructure, laboratory and administrative support
- Truly connected. We work together with hospitals and research institutes on a national and international level as well as industrial partners. Connection between science and society is very important to us. From our school lab – the Scienteens Lab – to the different outreach activities and collaborative partnerships with patient associations, we love to listen to society’s needs and share our passion for science
- Be part of a multicultural team. At the LCSB we have more than 50 nationalities. Throughout the year, we organise team-building events, networking activities and more
What awaits you in the TN team
- You will have access to state-of-the-art technologies, gold standard in vitro and in vivo models and advanced experimental protocols
- You will be embedded in a unique environment, working in close collaboration with computational and clinical teams, allowing to integrate functional studies in patient-based models with clinical and genetic data
- You will receive experienced feedback from research staff and support in submitting your own grant applications for further career development
- Contract type: Fixed Term Contract 12 Month
- Work hours: Full Time 40.0 Hours per Week
- Location: Belval
- Job reference: UOL06068
The yearly gross salary for every Postdoctoral Researcher at the UL is EUR 83099 (full time)
How to apply…
Applications should be submitted online and include:
- Detailed Curriculum Vitae including a list of publications
- Cover letter mentioning the reference number
- Description of past research experience and future interests
Early application is highly encouraged, as the applications will be processed upon reception. Please apply formally through the HR system. Applications by email will not be considered.
The University of Luxembourg embraces inclusion and diversity as key values. We are fully committed to removing any discriminatory barrier related to gender, and not only, in recruitment and career progression of our staff.
In return you will get…
- Multilingual and international character. Modern institution with a personal atmosphere. Staff coming from 90 countries. Member of the “University of the Greater Region” (UniGR)
- A modern and dynamic university. High-quality equipment. Close ties to the business world and to the Luxembourg labour market. A unique urban site with excellent infrastructure
- A partner for society and industry. Cooperation with European institutions, innovative companies, the Financial Centre and with numerous non-academic partners such as ministries, local governments, associations, NGOs …
- Find out more about the University
- Addresses, maps & routes to the various sites of the University
About the University of Luxembourg… University of Luxembourg is an international research university with a distinctly multilingual and interdisciplinary character. The University was founded in 2003 and has more than 6,700 students and more than 2,000 employees from around the world. The University’s faculties and interdisciplinary centres focus on research in the areas of Computer Science and ICT Security, Materials Science, European and International Law, Finance and Financial Innovation, Education, Contemporary and Digital History. In addition, the University focuses on cross-disciplinary research in the areas of Data Modelling and Simulation as well as Health and System Biomedicine. Times Higher Education ranks the University of Luxembourg #3 worldwide for its “international outlook,” #20 in the Young University Ranking 2021 and among the top 250 universities worldwide.
Características del Puesto
|Categoría de Puesto||Postdoctoral|