Postdoctoral Researcher Molecular and Cellular Biology – Tumor Biology

Area of research:

Scientific / postdoctoral posts

Starting date:

22.09.2023

Job description:

Our group focuses on the regulation of cell signaling in inflammation and cancer. We are part of the Institute of Biological and Chemical Systems- Functional Molecular Systems (IBCS-FMS) at the Karlsruhe Institute of Technology, Germany. The aim of the project is to investigate signaling pathways active in the tumor microenvironment and having an impact in pancreatic cancer. Pancreatic tumors are characterized by a desmoplastic stroma occupying up to 80% of the total tumor. This project will focus on the contribution of pancreatic stellate cells (PSCs) and cancer associated fibroblasts (CAFs) to the establishment of a desmoplastic microenvironment. In particular, the remodeling of the extracellular matrix and the immunoregulation of the tumor by PSCs/CAFs will be the focus. The candidate will apply a broad range of molecular, cell biology and immunological methods in vivo and in vitro. He/She is expected to manage the evaluation and the statistical analysis of the results as well as their publication in peer-reviewed journals and at (inter-) national conferences.

This research center is part of the Helmholtz Association of German Research Centers. With more than 42,000 employees and an annual budget of over € 5 billion, the Helmholtz Association is Germany’s largest scientific organisation.