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A postdoctoral research associate position is currently available in the laboratory of Dr. Zhongsheng You in the Department of Cell Biology and Physiology at the Washington University School of Medicine (WUSM) in St. Louis, Missouri. WUSM provides a superb research and training environment and is consistently ranked among the top medical schools in the country (http://medicine.wustl.edu). The You Lab investigates cellular responses to genotoxic stress with the goal to better understand and treat cancer. A current focus in this area is to investigate an emerging role of intracellular Ca2+ and Ca2+ signaling in the replication stress response and the DNA damage response that are essential for genome protection and tumor suppression (Li et al., Mol Cell 2019). Our lab also studies RNA surveillance mechanisms in cancer, focusing on the nonsense-mediated RNA decay (NMD) pathway. A major focus in this direction is to develop innovative tools for NMD analysis, and explore the interplay between NMD and DNA surveillance mechanisms and the potential of targeting this interplay for the treatment of leukemias (Nicklesss et al., Nat Med 2014; Cheruiyot et al., under review). We use a combination of experimental approaches and techniques, including cell biological and biochemical studies, a laser microirradiation system for DNA cutting in individual cells, genetically-encoded reporters, advanced cell imaging, high throughput compound screening and CRISPR/Cas9-based genetic screening to decipher DNA and RNA surveillance mechanisms and their crosstalk. For more information please visit our website: http://youlab.wustl.edu.
We are seeking a highly motivated individual who has a recent PhD degree and a strong background in cell biology and/or biochemistry. The successful candidate will work both independently and collaboratively as part of the team, and has excellent organizational and communication skills. Interested individuals should send a current C.V. and contact info for three references directly to Dr. Zhongsheng You (zyou@wustl.edu).
