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Announcement of post-doc scholarship for post-doc with a PhD degree within relevant field, molecular biology in C.elegans model systems. Analysis will include C.elegans genetics, EMS screening, CRISPR/Cas9, Immunohistochemistry, Immunoprecipitation and biochemistry.
Project
Telomere dynamics in C.elegans
Telomere is composed of repetitive DNA and its sequence-specific DNA-binding proteins. The telomere double-stranded DNA-binding proteins are evolutionally conserved and characterized from yeast to human model systems. However, there is no apparent homologs of such telomere-binding proteins in nematode C.elegans, suggesting hitherto unknow proteins might engage in telomere protection in C.elegans. We have recently identified the long-awaited telomere double-strand DNA-binding proteins in C.elegans, which we named DTN-1/2 (double-strand telomeric DNA-binding protein-1/2). Preliminarily, we have found that DTN-1/2 have redundant roles in the suppression of the DNA damage response (DDR), while they play opposing roles in the regulation of telomere length (i.e. DTN-1 is a negative regulator of telomere length while DTN-2 is a positive regulator). This training program is aimed at developing the relevant skills in analyzing the molecular mechanism of how DTN-1/2 ensure their functions as the protector of telomere and the regulator of telomere length homeostasis. The postdoctoral fellow will study the telomere dynamics in nematode C.elegans. Analysis will include C.elegans genetics, EMS screening, CRISPR/Cas9, Immunohistochemistry, Immunoprecipitation, and biochemistry. Candidates must have basic knowledge and experience in C.elegans model system.
Dnr/Reference
GU 2021-3467
Scholarship period
The scholarship covers a period of 12 months with possibility of prolongation up to a maximum of 24 months in total.
Preliminary start date: 2022-03-01 (can be negotiated)
Supervisor/contact person
For questions and additional information, please contact Assistant Professor:
Hiroki Shibuya, 0700060779, hiroki.shibuya@gu.se
Qualifications
- To be eligible for a post-doc scholarship, the recipient must hold a PhD degree within a relevant field (molecular biology in C.elegans model systems).
- The applicant must not have been employed at University of Gothenburg in the past two years.
- Please specify experiences, knowledge or interests necessary for taking part as a postdoc in this project. Remember that a scholarship is not an employment and the qualifications necessary might differ from what you could ask for from an employee.
Application
Written application, including reference number, is to be sent via e-mail to the supervisor and must include the following:
- CV
- Personal letter stating the reasons why the study suits the applicant (maximum one page)
- List of publications
- References (2)
Application deadline: 2022-02-07
Information regarding scholarships
- Scholarships do not give rise to sickness benefits, compensation from the Social Insurance Office or retirement pension.
- The scholarship sum is paid out quarterly
- Scholarships are tax-exempt
- A scholarship holder cannot be hired after the scholarship period due to tax reasons.
