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A Postdoctoral Position is available in the Department of Dermatology at UC San Diego in the Altman Clinical and Translational Research Institute. Our laboratory is interested in understanding the molecular mechanisms governing how epidermal stem cells self-renews and differentiates. Our model system involves using regenerated human skin that we genetically manipulate to determine the impacts of gene loss or gain of function on skin regeneration. Recently we have discovered several key proteins that degrade differentiation specific mRNAs to allow for epidermal stem cell self-renewal (Cell Stem Cell and Molecular Cell).

We have also found that transcription elongation controls various aspects of skin homeostasis including renewal, differentiation, immune response, and hair follicle formation. We have mouse knockout models to study the impacts of loss of transcription elongation on epidermal, hair follicle, immune response, and sweat formation during development.

For an example of our most recent work please use this link:

https://www.nature.com/articles/s41467-021-21067-w

For papers from our lab please us this link:

https://pubmed.ncbi.nlm.nih.gov/?term=george+sen&sort=date

Successful candidates should have a PHD, MD, or equivalent degree with training in Molecular Biology, Genetics, Developmental Biology, Bioinformatics, Stem Cell Biology, mouse work, mouse genetics, and mammalian cell culture. The candidate must have documented peer-reviewed research productivity.

If interested, please send CV and cover letter providing information on research background, interests, and contact information for 3 references to Dr. George Sen (gsen@health.ucsd.edu).

For more information about the lab please visit our website:https://medschool.ucsd.edu/som/dermatology/research/labs/sen-lab/Pages/default.aspx