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Do you want to be part of an international consortium committed to characterizing human transporters at the interface between biological systems and the environment?
We are looking for a project scientist to plan, carry out and supervise desorphelination studies on human transporters using proteomic / metabolomic approaches in cooperation with the proteomics / metabolomics facility of CeMM. The successful candidate will be part of the RESOLUTE consortium ( https://re-solute.eu/ ) and will be based in the laboratory of Giulio Superti-Furga (CeMM, Vienna). It will have the possibility of carrying out data generation campaigns to unlock human transporters in close collaboration with a group of 120 scientists, distributed in 6 pharmaceutical companies, 1 biotechnology and 6 university research institutes, constituting a powerful and unique professional network.
Desired requirements and qualifications
- PhD in cell biology, biochemistry, biotechnology or similar
- Experience in mammalian cell culture (immortalized cell line models)
- Experience with MS-based analytical techniques (LC-MS / MS) and MS-based data analysis (e.g. Proteome Discoverer, MassHunter, MaxQuant, or similar) in affinity and / or proximity proteomics (BioID / APEX)
- Experience with relevant statistical models (SAINT, Perseus, linear models) is an advantage
- Rigor and talent in the organization
- Ability to work in a team and pursue objectives in a targeted manner
- Excellent written / oral communication skills in English
The RESOLUTE consortium
From July 1 from 2018, the RESOLUTE consortium is supported by the Initiative for Innovative Medicines (IMI, www.imi.europa.eu) with 13 partners from the academic world and the pharmaceutical industry and is coordinated by the Superti-Furga laboratory. The RESOLUTE consortium’s mission is to deorphelinate human SLC transporters on a large scale and to unlock them as potential pharmacological targets. With a well-defined plan of action, we are currently pushing for a paradigm shift in the science of human cell transporters by creating a massive historical advance in the knowledge of hundreds of individual transporters and how they work together.
The Superti-Furga laboratory
The Superti-Furga group ( http://superti-furga-lab.at/ ) is made up of an international team of more than 30 scientists working together on understanding the function of drugs at the molecular level. The laboratory is studying how cells and biological systems in general manage access to the environment through cell transport. In particular, how access to nutrients and the energy source is adjusted to the metabolism and the needs of each type of cell. In addition, the laboratory has launched functional precision medicine approaches. The laboratory operates on a truly multidisciplinary basis and involves functional genomics and proteomics, structural analysis, chemical biology, high content imaging, bioinformatics and physiology, reflecting the mix of expertise of the members of the laboratory.
Selected publications:
Bigenzahn et al, LZTR1 is a regulator of ubiquitination and RAS signaling, Science 2018.
Rebsamen et al, SLC38A9 is a component of the lysosomal amino acid detection mechanism that controls mTORC1, Nature 2015.
Cesar-Razquin et al, A Call for Systematic Research on Solute Carriers, Cell 2015.
The Institute
CeMM ( www.cemm.at ) is a flagship institute of biomedical research in the heart of Europe, in Vienna. CeMM is committed to respecting the highest scientific standards. The environment is very collaborative, dynamic and international. One of the advantages of CeMM is that it is close to the campus of the Vienna Medical University and the General Hospital (AKH). This enables the fruitful interaction of basic scientists with clinicians, and the use of advanced models and technologies for biological questions relevant to the disease. According to a study by The Scientist, CeMM is ranked as the best European place to work in Academia 2012, internationally CeMM appears in fourth place. The official language of CeMM is English, and more than 45 different nationalities are represented at the institute.
We offer
It is a fantastic opportunity for a project scientist to join an exciting project in an inspiring and dynamic setting. In return, we offer an excellent package of benefits, including health insurance, corporate health care, competitive vacation allowance, daily bonus for the internal cafeteria and gross monthly salary of 3,889.50 EUR, – (according to the recommendations of the FWF ). We provide an excellent working environment for passionate scientists and we are proud to be an international and diverse group. The contract for the position will be limited to 3 years since the project ends in 2023. Other projects are expected to follow.
Request details
CeMM aims to promote equal opportunities for all with the right combination of talents, skills and potential. We accept applications from candidates from diverse backgrounds. Please click on the link https://cemm.jobbase.io/job/w1fnnjjm to apply online with your application documents (cover letter, CV and names and contact details of 2 referees).
Closing date for applications: March 31, 2020 . Applications will be reviewed on an ongoing basis. The preferred start date is June / July 2020.
