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JOB SUMMARY Postdoctoral position to study the impact of cellular senescence in neurodegenerative diseases
This is a joint position between the Kapahi and Campisi laboratories at the Buck Institute for Research on Aging. The Kapahi and Campisi labs are collaborating to study the role of advanced glycation endproducts (AGEs) in cellular senescence and its impact on Alzheimer’s disease. This is being achieved by using an interdisciplinary approach combining genetic, pharmacological, biochemical, and genomic approaches in invertebrate model systems C. elegans, mice, and human samples. The broader significance of this research is to help uncover the role of diet and AGEs in the etiology of age-related human diseases like diabetes and Alzheimer’s disease.
The current position involves studying the role of glucose and Advanced Glycation Endproducts (AGEs) in diabetes and neurodegeneration using mice, and IPS derived cells. We propose to examine the mechanisms involved in synthesis and detoxification of Advanced Glycation Endproducts (AGEs) and how they cause cellular damage.
QUALIFICATIONS Previous background in cellular senescence and mouse genetics will be an advantage but not necessary. The candidate will receive training in specific area(s) of research to progress towards an independent career.
Selected publications Chaudhuri, J., Bose, N., Gong, J., Hall, D., Rifkind, A., Bhaumik, D., Peiris, T. H., Chamoli, M., Le, C. H., Liu, J., Lithgow, G. J., Ramanathan, A., Xu, X. Z. and Kapahi, P. “A Caenorhabditis elegans Model Elucidates a Conserved Role for TRPA1-Nrf Signaling in Reactive alpha-Dicarbonyl Detoxification.” Curr Biol 26, no. 22 (2016): 3014-3025. PMC5135008 Chaudhuri J, Bains Y, Guha S, Kahn A, Hall D, Bose N, Kapahi P, et al. The Role of Advanced Glycation End Products in Aging and Metabolic Diseases: Bridging Association and Causality. Cell Metab. 2018;28(3):337-52. PMCID:PMC6355252 Wiley CD, Liu S, Limbad C, Zawadzka AM, Beck J, Demaria M, Campisi J, and Kapahi P, et al. SILAC Analysis Reveals Increased Secretion of Hemostasis-Related Factors by Senescent Cells. Cell Rep. 2019;28(13):3329-37 e5. PMCID:PMC6907691 Campisi J, Kapahi P, Lithgow GJ, Melov S, Newman JC, Verdin E. From discoveries in ageing research to therapeutics for healthy ageing. Nature. 2019;571(7764):183-92. PMCID:PMC7205183 Laberge RM, Sun Y, Orjalo AV, Patil CK, Freund A, Zhou L, Kapahi P, and Campisi J. MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation. Nat Cell Biol. 2015;17(8):1049-61. PMCID:PMC4691706
ABOUT US Our success will ultimately change healthcare. At the Buck, we aim to end the threat of age-related diseases for this and future generations by bringing together the most capable and passionate scientists from a broad range of disciplines to identify and impede the ways in which we age. We are an independent, non-profit institution located in Marin County, CA, with the goal of increasing human healthspan, or the healthy years of life. Globally recognized as the pioneer and leader in efforts to target aging—the number one risk factor for diseases including Alzheimer’s, Parkinson’s, cancer, macular degeneration, heart disease, and diabetes—the Buck seeks to help people live better longer.
The Buck Institute has an excellent postdoctoral research program. We offer competitive salaries, excellent benefits, a dynamic work environment, and new state-of-the-art facilities.
LIVING BETTER LONGER TOGETHER Buck Institute for Research on Aging is an equal opportunity employer. Buck Institute seeks candidates whose experience and qualifications will enable them to contribute to our dedication to diversity and excellence. We are committed to building an organization that represents a variety of backgrounds, perspectives and skills. We welcome the unique contributions that you can bring in terms of education, opinions, culture, ethnicity, race, sex, gender identity and expression, nation of origin, age, languages spoken, veteran’s status, color, religion, disability, sexual orientation and beliefs.
TO APPLY Interested candidates should apply online and upload a CV and cover letter including contact information for three professional references. For questions regarding this position, please email Pkapahi@buckinstitute.org or visit https://www.buckinstitute.org/lab/kapahi-lab/
