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Postdoctoral Training in Transcription and the Maintenance of Genome Instability
in the Svejstrup laboratory at the Department of Cellular and Molecular Medicine
Faculty of Health and Medical Sciences, University of Copenhagen
We seek two or more talented and highly motivated postdocs interested in investigating the interface between gene transcription, RNA metabolism and genome stability to join the laboratory led by Professor Jesper Svejstrup FRS.
The successful candidate(s) will be employed as a postdoctoral researcher at the Department of Cellular and Molecular Medicine (ICMM) at the Faculty of Health and Medical Sciences, University of Copenhagen, and the employment period is for 3 years starting 1 October 2020, or soon thereafter, with the possibility of extension.
About the lab and the institute
In September 2020, the Svejstrup Laboratory will re-locate from the Francis Crick institute in London (http://www.crick.ac.uk/Jesper-svejstrup) to the ICMM.
Dr Svejstrup’s laboratory focuses on various aspects of transcription-associated genome instability and the cellular response to DNA damage obstructing transcription. Details of recent papers and research projects currently being undertaken can be found in the link above.
Research techniques used in the laboratory include: Cell biology, Biochemistry (including SILAC proteomics and reconstitution of key processes with purified factors in vitro) and modern Genome-wide techniques (ChIP-Seq, RNA-Seq, GRO-Seq, etc), as well as Genomic screening (siRNA and CRISPR screens).
Svejstrup lab represents cutting-edge interdisciplinary research and training, and will be located at ICMM in the new Mærsk Tower science building and at Panum. We will have access to state-of-the-art facilities for mass spectrometry, flow cytometry, cell engineering, and next-generation sequencing.
Project description
The positions are potentially related to several different projects: 1) Investigation aimed at gaining a deeper understanding of the molecular processes underlying transcription-coupled repair (TC-NER), with a particular focus on the transcription-repair coupling factors CSA and CSB, both encoded by genes that are mutated in the severe neurological disorder Cockayne syndrome. 2) A second area of interest is related to the process of transcript elongation, and in particular the mechanisms that allow RNA polymerase II to transcribe a gene with high fidelity and without loss of genome stability. 3) And a third new research area investigating transcription-related factors that govern nucleus-cytoplasm communication, and which ensure that the entire process of gene expression (from transcription in the nucleus to mRNA translation in the cytoplasm) is correctly regulated.
Any postdoctoral fellow joining the laboratory will be encouraged to help develop their own project. A high degree of independence will be granted and expected.
Principal mentor will be Jesper Svejstrup, ICMM, jesper.svejstrup@crick.ac.uk
Your profile
You have a PhD in Biochemistry, Molecular Cell Biology or similar You possess research experience and publication records in relevant fields, ideally with prior experience in one or more of the topics mentioned above Proficient communication skills and ability to work in teams Excellent English skills written and spoken
Assessment of applicants
We will primarily consider prior research experience in the field, and the level of documented, internationally competitive research. The potential ability to attract external funding will be considered together with outreach qualifications. Teaching qualifications are not mandatory or required, but documented teaching qualifications and teaching experience may be considered.
Place of employment
The place of employment is at the Department of Cellular and Molecular Medicine (ICMM), University of Copenhagen. ICMM offers a creative and ambitious scientific environment, with many different nationalities represented. ICMM aims to produce research with high international impact focusing on the functional cell, its genetic components and molecular cellular mechanisms in a medical context. ICMM currently comprises five research programs, three high profile Research Centers as well as a number of international research groups. The scientists at ICMM are involved in high quality research based undergraduate and graduate teaching programs at the University of Copenhagen. More information can be found at www.icmm.ku.dk.
Terms of employment
The employment as postdoctoral researcher is a full time and fixed-term position for 3 year(s) with the possibility of extension contingent upon funding. Starting date is October 1st 2020 or after agreement.
Salary, pension and terms of employment will be in accordance with the agreement between the Ministry of Finance and AC (Danish Confederation of Professional Associations). Currently, the monthly salary starts at 34,654.76 DKK/ approx. 4,620 Euro (April 2020-level). Depending on qualifications, a supplement may be negotiated. The employer will pay an additional 17.1 % to your pension fund.
Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years.
The position is covered by the “Memorandum on Job Structure for Academics Staff at the Universities” of January 2020.
Questions
For further information please contact Jesper Svejstrup, ICMM, jesper.svejstrup@crick.ac.uk
Foreign applicants may find this link useful: www.ism.ku.dk (International Staff Mobility).
Application procedure
Your online application must be submitted in English by clicking ‘Apply now’ below. Furthermore, your application must include the following documents/attachments – all in PDF format:
Motivated letter of application (max. one page) CV incl. education, work/research experience, language skills and other skills relevant for the position A certified/signed copy of a) PhD certificate and b) Master of Science certificate. If the PhD is not completed, a written statement from the supervisor will do. List of publications Teaching portfolio if applicable
Application deadline: July 1st 2020, 23.59pm CET
We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.
The further process
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor. Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.
You can read about the recruitment process at http://employment.ku.dk/faculty/recruitment-process/
The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.
University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates regardless of age, disability, gender, nationality, race, religion or sexual orientation. Appointment will be based on merit alone.
