Postdoctoral position in decision-making in aging and Alzheimer’s disease, University of Minnesota

The Lesné lab at the University of Minnesota seeks a postdoctoral fellow for an NIH-funded project focused on alterations of decision-making in aging and Alzheimer’s disease.

A central question in aging and Alzheimer’s disease (AD) is when (and if so, how) neural substrates underlying decision-making are altered and whether impairment in decision-making can be attenuated or halted. This effort seeks to uncover the role of aging, sex and AD-associated pathology on economic decision-making in mice. To uncover whether and how Aβ-dependent mechanisms induce changes in circuits underlying various forms of decision-making, we will use mouse models of AD combined with a unique behavioral platform designed to resolve decision-making complexities, whole-brain imaging and three parallel interventions (genetic, pharmacologic and optogenetic).

Experience with genetically engineered mouse models is preferred but not required. Expertise in mouse behavior, molecular biology, biochemistry, confocal image analysis and coding is desired.

We seek motivated candidates who are intellectually and experimentally flexible. Researchers will work as part of a team combining mouse behavior, protein biochemistry, neuropathology, viral engineering, cell biology and transcriptomics to push the boundaries of our current research projects.

Qualifications: Applicants should hold (or soon receive) a Ph.D. in neuroscience or a related discipline. Successful applicants should be highly self-motivated, have outstanding experimental skills, and be able to think independently but also work well in a team.

Environment: The laboratory is located in the Wallin Medical Biosciences Building at the University of Minnesota Twin Cities campus which enjoys a vibrant and collegial scientific environment. Minneapolis and St. Paul offer great culture, healthy lifestyle, kindhearted people, great economy (16 Fortune 500 headquarters, $2.9 billion in Medical Science R&D invested), and so much to do.

To apply:

Please e-mail: Dr. Sylvain Lesné, PhD

Associate Professor of Neuroscience

University of Minnesota Minneapolis, MN 55414

lesne002@umn.edu https://lesnelab.org/