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The NMR Lead Researcher will join an inter-disciplinary Blue Sky initiative on “Seeing the Invisible in Protein Kinases”, which is supported by US$35M in institutional funding by the St. Jude Children’s Research Hospital. The project will extend the ultra-high field NMR spectroscopy and biochemistry approaches developed recently by the Kalodimos lab (Science 2020, 370, eabc2754) to study the human kinome. This is a large-scale project that aims to detect and structurally characterize the distinct conformational states populated by kinases, and to dissect the mechanisms of allosteric regulation and those underpinning oncogenic and drug-resistance mutations. The unparalleled NMR center at St. Jude includes three 600 MHz, two 700 MHz, four 800 MHz, 850 MHz, and the first 1.1 GHz. We expect this initiative to have a profound impact on the field, transforming our understanding of protein kinases.
Preferred skills and experience:
- Experienced in using multidimensional NMR spectroscopy to study proteins including collection and analysis of three-dimensional noesy data.
- Experience in using both automated and manual methods for assignment of backbone and methyl groups.
- Working knowledge of protein dynamics using CEST.
- Experience in data processing using NMRPipe.
- Experienced in NMR structure calculation and refinement.
- Independently motivated, detail oriented and good problem-solving ability.
- Excellent organizational skills, with an ability to embrace change and multi-task in an extremely fast-paced environment.
- Excellent communications skills.
St. Jude Children’s Research Hospital offers a remarkable opportunity to perform cutting edge research with outstanding institutional support and exceptional shared core facilities in an environment of open collaboration, educational advancement and training opportunities. St. Jude is consistently ranked on Fortune Magazine’s and Glassdoor’s “100 Best Places to Work” for companies with 1,000 or more employees. We are located in the heart of Memphis, Tennessee, a vibrant and friendly city at the historic American crossroads of music, trade, food, and culture. Mild winters and beautiful green outdoor spaces are part of the reasons why Forbes recently named Memphis the 4th happiest city in which to work. Cost of living and high quality of life are other attractions; Money magazine listed Memphis as one of the least expensive cities in which to raise a child. St. Jude facilities and salaries are highly competitive
Responsibilities
- Performs tasks related to the research project independently, but within broad guidelines and subject to periodic review by supervisor or other research staff.
- Independently apply NMR techniques and procedures associated with chemical shift assignment, structure determination, and dynamics studies with minimal assistance from other research staff.
- Analysis of CEST relaxation profiles.
- Structure calculations using CYANA.
- Independently troubleshoot, solve difficult problems, and propose solutions related to research project design and execution with limited support other research staff.
- Work effectively in a collaborative team environment where results are achieved through influence, cooperation, and the incorporation of multiple points of view.
Minimum Education
- Bachelor’s degree in relevant scientific area is required
Minimum Experience
- Five (5) years of relevant, post-degree work experience is required with Bachelor’s degree
- Two (2) years of relevant post-degree work experience is required with a Master’s degree
- No experience is required with a PhD in relevant scientific areas. PhD in NMR spectroscopy is highly preferred.
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