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The interdisciplinary Cancer Program at the Centre for Single-Cell Omics is aiming to improve the outcome of cancers with unmet medical need, e.g. pancreatic, lung and liver cancer. We are cutting-edge technologies including single-cell omics to dissect the heterogeneity of cancer and develop more effective therapies for our cancer patients. It has now become evident that cancer heterogeneity is not only related to the existence of different sub clones within the tumor, but heterogeneity is further enhanced by so-called cancer stem cells at the subclonal level. These cells are responsible for intraclonal heterogeneity, promote metastasis and are inherently resistant to conventional therapies. We are performing internationally leading research on cancer stem cell biology with a strong emphasis on translational research (e.g. Cell Stem Cell 2007, 2011, 2015, Nat Methods 2014, Cell Metab 2015, Cancer Cell 2008, 2014, 2016, Nat Comm 2018, 2020).
We are particularly interested in the following research areas:
• Understanding the cellular origin of pancreatic cancer stem cells;
• Dissecting the heterogeneity of (circulating) cancer cells at single-cell level;
• Bioinformatic analysis of large-scale single-cell omics data
• Studying the genetic and epigenetic evolution resulting in resistance to therapy;
• Identifying novel therapeutic targets using single-cell functional genomics;
• Metabolism in cancer stem cell
• Epigenetic regulation of cancer stem cells
• Immunology of cancer stem cells
• Designing and testing novel immunotherapies (e.g. tunable CAR T-cell) and CSC-targeting therapies;
Requirements
PhD, MD or equivalent biomedical degree. A track record of scientific excellence in biomedical sciences.
We offer
Shanghai Jiao Tong University School of Medicine offers a rich and collaborative intellectual environment with state-of-the-art infrastructure. We provide competitive salaries and benefits for PostDocs and Faculty. Housing allowance will be provided, dependent on demonstrated scientific excellence. With English serving as the common communication channel, proficiency in Chinese is not required. However, we do provide free courses in Mandarin Chinese as well as Chinese culture. The Center for Single-Cell Omics (www.shsmu.edu.cn/sph-cscomics/index.htm), Shanghai Jiao Tong University School of Medicine, is located on the School of Medicine Campus in downtown Shanghai and equipped with ultramodern facilities, including four core facilities for single cell processing and analysis.
Applicants should send their cover letter and CV to Prof Christopher Heeschen christopher.heeschen@icloud.com.
