Offer Description

Offer Description

The Faculty of Natural Sciences at the Chemnitz University of Technology offers an employment for a Research Assistant/PhD candidate at the professorship Inorganic Chemistry. The Kretschmer Lab utilizes main-group chemistry for the design and understanding of catalytic reactions and novel materials.

The advertised position will be involved in the development of new concepts that combine main-group element and transition-metal chemistry aiming to acccess new catalysts and photoactive materials. The work includes organometallic synthesis, reactivity and catalysis studies as well as kinetic method aiming to understand the reaction mechanisms. Furthermore, the position is associated with teaching dueties (2 hours/week).

The position (50 %, E 13 TV-L) is available for a three-year period and should be filled between January 1st and March 1st 2024. The successfull applicant should meet the requirements listed below. Please send your full application electronically as a single PDF file by e-mail before October 2nd, 2023 using the reference number AC-WM-5 to the address shown below. In your application, please include the usual documents including a cover letter elaborating your fit to the job requirements, a CV, copies of university certificates, and contact details for two academic referees.

All relevant information on this job offer are found on the following website: https://www.tu-chemnitz.de/verwaltung/personal/stellen/211031_17_LH.php

The Laboratory of Process Technology (NeptunLab) at the Department of Microsystems Engineering (IMTEK) at the University of Freiburg offers several Ph.D. positions (m/f/d) starting at the earliest possible date. The position is within the „Dilution Energy Systems“ project and is limited until June 30, 2026.

We offer several Ph.D. Positions at the NeptunLab. The NeptunLab is the highly interdisciplinary research group of Prof. Bastian E. Rapp (Professor of Process Technology) at the Department of Microsystems Engineering (IMTEK) at Freiburg University. The work of the NeptunLab is published in the most important international journals including Lab-on-a-Chip, Advanced Materials, Angewandte Chemie, Science and Nature and has been featured in national and international radio and print media including the BBC, the New York Times and the Discovery Channel.

About the project

Ensuring energy stability while significantly reducing our carbon footprint will require novel concepts to tackle climate crises. The decarbonization of power supply is currently being addressed by extending our renewable capacities, such as photovoltaics. Heat storage, on the other hand, has seen significantly less innovative solutions, with heat pumps being the currently favored option.

This project will investigate a novel concept for providing so-called thermal batteries on the basis of dilution energy. This concept essentially allows converting heat to a liquid that can be transported, stored and released wherever required. Theoretical assessments of this concept predict a storage density exceeding current state-of-the-art reversible heat storage by one order of magnitude.

Activities and Responsibilities

• Screening of viable energy storage materials
• Development of a mixed-phase concentration module suitable for heat storage
• Development of a device for the controlled energy release through a microfluidic mixing device for optimized convective mixing
• Development of a prototype system for in-field validating and figure-of-merit analysis

Qualification Profile

• Master’s degree/Bachelor’s degree/Studies in chemistry, materials science, engineering, sustainable materials or related subjects
• Excellent academic track record
• Excellent English skills in reading and writing
• You should be a team player with ambitions who can conduct research projects independently
• You should be a creative mind without causing excessive chaos around you
• You should be able to structure and document your work properly

Benefits

• An interdisciplinary work environment with a team of motivated scientists that strive to develop clever solutions for scientific and industrial problems with societal implications
• Well-funded projects with access to excellent state-of-the art infrastructure, generous lab space and scientific equipment
• An aspiring young team with great emphasis on publications and publicity
• A lab structure that promotes the development of individual members and fosters open-minded scientific discussions
• A strong focus on the career development of the candidate, including submitting to and attending the most relevant international conferences and summer schools
• An environment that supports start-up mentality – if your research is industrially applicable and promising, we will move toward commercialization of your solution
• Payment of TV-L E13 65% (full time)
• Depending on the performance of the candidate, the Ph.D. degree is generally completed within three years

Your Application

Please consult the “before you apply” section of the laboratory homepage http://www.neptunlab.org/index.php/open-positions#BeforeYouApply

Make sure you attach all relevant documents (pdf format preferred)

• Letter of motivation: Why do you apply for this position?
• Curriculum Vitae
• Academic track record (recent grades)
• References (2 – 3 references with contact details)

The University of Freiburg strives to employ more women in academia and research. We therefore expressly encourage women to apply. We welcome applications from candidates with disabilities. If multiple candidates prove to be equally qualified, those with disabilities or with equivalent status pursuant to the German Social Code IX (SGB IX) will receive priority for employment.

Submission

Please submit your application (in English only, and as one MERGED PDF file) including your motivation letter, CV, copy of degree certificates, and 2 – 3 references by November 30, 2023, to Dr. Peilong Hou (peilong.hou@neptunlab.org). Please submit copies only, as your application will not be returned to you.

Thinking of doing your PhD in the Life Sciences? The International PhD Programme (IPP) Mainz is offering talented students the chance to work at the cutting edge of research. As an IPP PhD student, you will join a community of exceptional scientists working on diverse topics ranging from how organisms age or how our DNA is repaired, to how epigenetics regulates cellular identity or neural memory.

Activities and responsibilities:

In the field of “Ageing & Disease”, the research group of Björn Clausen offers the following PhD project:

Colorectal cancer (CRC) is a leading cause of cancer-related deaths among men and women worldwide, with increasing incidence rates, in particular in young people. CRC can arise sporadically or due to chronic inflammation, and both genetic disposition as well as environmental factors contribute to the development of CRC. Risk factors include age and lifestyle such as poor dietary habits, alcohol consumption, smoking, obesity, and lack of physical activity, and possibly viral infections. Patients with long-standing inflammatory bowel diseases exhibit a higher risk to develop colitis-associated colorectal cancer (CAC).

B cells are an important part of the immune cell infiltrate of tumors, and their contribution to tumor initiation, development, and immunosurveillance is complex with both pro- and anti-tumorigenic effects. Recent studies implicate a fundamental role of B cells in shaping anti-tumor responses through several mechanisms. While IgA⁺ plasma cells regulate bacterial populations in the gut lumen in steady state, plasma cell-derived tumor-specific IgG1 antibodies mediate cell cytotoxicity and phagocytosis of tumor cells. In addition, B cells present tumor-specific antigens via MHCI and MHCII to T cells inducing their anti-tumor effector function. B cells also regulate the immune response within the tumor microenvironment through the release of cytokines, such as IFN-g, IL-12, or IL-10. CRC patients show substantial alterations in their B cell compartment, with increasing numbers of IL-10 producing B cells in advanced tumors and metastases. CRC patients with tumors highly infiltrated by CD20⁺ B cells display significantly improved survival, which suggests an anti-tumor role of B cells. In line, B cells are closely associated with CD8⁺ cytotoxic T cells, which are important in antigen-specific immunity against tumors. Antibody-independent mechanisms such as antigen presentation, cytokine production, direct cytotoxicity, and indirect effects through modulation of other immune cells have been demonstrated to be of great importance. Thus, whether B cells promote or inhibit tumor growth depends on different variables, such as temporal and spatial settings, as well as on the composition of B cell subsets. Therefore, a phenotypical and functional characterization of B cells in CRC tumor initiation and progression is of great interest with a possible therapeutic benefit.

PhD project: The role of B cells in Colorectal Cancer Development and Progression

The molecular and cellular mechanisms underpinning inflammatory processes that promote epithelial transition to carcinogenesis are still only insufficiently characterized, and especially how B cells contribute to these processes. We started investigating the role of B cells in the inflammatory phase, and at later time points of tumor development/progression in the well-established animal model of inflammation-induced CRC (AOM/DSS). We could show that B cells exert an important role by using B cell-deficient mice (JHT mice), which were completely resistant to AOM/DSS-induced inflammation as well as CRC development. Further, we could show that B cell-specific secretion of the immunosuppressive cytokine IL-10 drives CAC development, whereas it does not affect the inflammatory phase of CAC development.

In this proposed project, we will further elucidate the role of B cells in CAC using the AOM/DSS model. We will perform a detailed in vivo and in vitro analysis of different transgenic animals, manipulating, for example, antibody secretion using mice that are not able to secrete antibodies (IgMi mice). We will further use mice that allow us to delete B cells at any desired time point of CRC development to investigate the temporal/spatial role of B cells in colon carcinogenesis (iDTRCD19-cre mice).

In addition, we will employ a non-inflammatory model of sporadic CRC since preliminary data also show a significant role of B cells in this tumor entity. Besides these animal models, we will perform different molecular methods, flow cytometric analysis, immunohistochemistry as well as single cell and bulk RNA sequencing from tumors as well as the tumor microenvironment. We will create organoids, if possible, also from human tissue samples.

Finally, we will translate our experimental findings to the clinic by using human CRC samples from patients with inflammation-induced CRC in comparison to patients suffering from sporadic CRC and investigate the contribution of B cells.

Of note, this project is jointly conducted by the Hövelmeyer and Clausen laboratories at the Institute for Molecular Medicine in Mainz, as funded by the established DFG CRC 1292.

If you are interested in this project, please select Clausen (Canc) as your group preference in the IPP application platform.

What we offer:

• Exciting, interdisciplinary projects in a fully international environment, with English as our working language
• Advanced training in scientific techniques and professional skills
• Access to our state-of-the-art Core Facilities and their technical expertise
• Fully funded positions with financing until the completion of your thesis
• A lively community of more than 190 PhD students from 44 different countries

Requirements:

Are you an ambitious, young scientist looking to push the boundaries of science while interacting with colleagues from multiple disciplines and cultures? Then the IPP is your opportunity to give your scientific career a flying start!

All you need is:

• Master or equivalent
• Interactive personality & good command of English
• 2 letters of reference

For more details on the projects offered and how to apply via our online form, please visit https://www.imb.de/phd

The deadline for applications is 8 November 2023. Interviews will take place at IMB in Mainz on 22-24 January 2024.

Starting date: 1 March 2024 – 1 August 2024

Thinking of doing your PhD in the Life Sciences? The International PhD Programme (IPP) Mainz is offering talented students the chance to work at the cutting edge of research. As an IPP PhD student, you will join a community of exceptional scientists working on diverse topics ranging from how organisms age or how our DNA is repaired, to how epigenetics regulates cellular identity or neural memory.

Activities and responsibilities:

In the field of “Ageing & Disease”, the research group of Björn Clausen offers the following PhD project:

The oral mucosa represents a barrier tissue to the environment where the balance of immunity and tolerance is vital, as it is constantly exposed to pathogens and harmless foreign antigens, including commensals. A breakdown of this balance leads to dysbiosis resulting in periodontitis, an infection-induced inflammatory disease characterized by irreversible destruction of the tooth-supporting tissues including loss of the underlying bone. Moreover, it is considered a risk factor for life-threatening conditions such as cardiovascular disease. Dendritic cells (DC), including Langerhans cells (LC), have the unique capacity to promote both tolerogenic and inflammatory immune responses. Hence, in order to design effective therapeutic strategies to treat periodontitis and reduce the risk of developing comorbidities, it is essential to understand how DC in the oral mucosa maintain immune homeostasis.

PhD project: E-cadherin and β-catenin signaling in dendritic cells for the maintenance of immune homeostasis in the oral mucosa

One pathway that plays a crucial role in DC homeostasis and tolerance induction is E-cadherin/β-catenin signaling. The cell adhesion molecule E-cadherin is only expressed by LC and we recently showed that it is involved in the 2-step process of their differentiation in the oral mucosa. Notably, to what extent E-cadherin/β-catenin signaling regulates LC/DC homeostasis and function in the oral mucosa is not known. In pilot experiments, we analyzed the oral mucosa of transgenic mice lacking E-cadherin in CD11c⁺ cells (CD11c-Ecad^DEL) and observed an altered LC subset distribution and a dramatically changed morphology with more rounded cell bodies and fewer dendrites compared to controls. In the proposed project a detailed in vivo and in vitro analysis of CD11c-Ecad^DEL and β-catenin deficient (CD11c-βcat^DEL) mice will be performed. First, we will assess LC and DC homeostasis, activation and migration in the different oral tissues by high-dimensional flow cytometry as well as the impact of CD11c-specific E-cadherin or β-catenin deletion on other immune cell populations. Moreover, we detected oral dysbiosis in our CD11c-Ecad^DEL mice and therefore, a detailed taxonomic microbiota analysis will be performed in this project. Since persistent microbial dysbiosis results in inflammation and subsequently alveolar bone loss, we will analyze the oral tissues of CD11c-Ecad^DEL and CD11c-βcat^DEL mice for T cell infiltration and inflammatory cytokines. Bone loss will be monitored by micro computed tomography (µCT) scans. Finally, in different mouse models of periodontitis (P. gingivalis- and ligature-induced periodontal disease) we will interrogate the impact of E-cadherin/β-catenin signaling on LC/DC during infection and inflammation. Applying single-cell RNA sequencing the molecular pathways affected by E-cadherin/ β-catenin signals in oral mucosal LC/DC will be deciphered. Our expected findings may thus have important implications for designing improved LC/DC-based strategies for the treatment of periodontal disease.

If you are interested in this project, please select Clausen (DC) as your group preference in the IPP application platform.

What we offer:

• Exciting, interdisciplinary projects in a fully international environment, with English as our working language
• Advanced training in scientific techniques and professional skills
• Access to our state-of-the-art Core Facilities and their technical expertise
• Fully funded positions with financing until the completion of your thesis
• A lively community of more than 190 PhD students from 44 different countries

Requirements:

Are you an ambitious, young scientist looking to push the boundaries of science while interacting with colleagues from multiple disciplines and cultures? Then the IPP is your opportunity to give your scientific career a flying start!

All you need is:

• Master or equivalent
• Interactive personality & good command of English
• 2 letters of reference

For more details on the projects offered and how to apply via our online form, please visit https://www.imb.de/phd

The deadline for applications is 8 November 2023. Interviews will take place at IMB in Mainz on 22-24 January 2024.

Starting date: 1 March 2024 – 1 August 2024

Thinking of doing your PhD in the Life Sciences? The International PhD Programme (IPP) Mainz is offering talented students the chance to work at the cutting edge of research. As an IPP PhD student, you will join a community of exceptional scientists working on diverse topics ranging from how organisms age or how our DNA is repaired, to how epigenetics regulates cellular identity or neural memory.

Activities and responsibilities:

In the field of “Ageing & Disease”, the research group of Wolfram Ruf offers the following PhD project:

Bone marrow-resident hematopoietic stem and progenitor cells (HSPC) are the source of all mature blood cells and replenish the body needs continuously in homeostasis and challenges throughout the life of the host. Although hematopoietic stem cells (HSCs) are mainly quiescent, they reversibly switch to proliferation upon challenges, such as infection, bleeding, or circadian rhythm. HSCs become dysfunctional in aging by incompletely understood cues from the bone marrow environment. This results in imbalances in the differentiation of HSPC that results in more inflammation (myeloid skewing) and age-related pathologies. Interactions of HSPC with various cellular and soluble (growth factors, extracellular vesicles) components of the bone marrow microenvironment crucially regulate the developmental fate of HSPC and proteases of the coagulation system have been shown to contribute to both matrix remodeling and regulation of homeostasis or mobilization of HSPC (extravascular coagulation signaling). Mutation or deficiencies of components of the coagulation system have been implicated in the regulation of HSPC in aging mouse models.

PhD project: Coagulation receptors in aging

The aim of the project is to determine the contribution of extravascular coagulation and immune signaling mechanisms to unbalanced hematopoiesis in aging with a long-term goal to possibly identify rejuvenation strategies. The work of the PhD candidate(s) will include the analysis of recently identified different mouse models with accelerated aging phenotypes and apply state of the art single cell technologies to characterize HSPC phenotypes and function. Characterization of the bone marrow environment by proteomics (e.g. of extracellular vesicles) may also be required to identify underlying molecular mechanisms for altered HSPC output in aging. Theoretical and practical knowledge in molecular and cell biology and/or protein chemistry are expected for successful candidates. The candidate should have an interest in systems biology approaches and develop skills to apply bioinformatics on newly generated and available omics data sets.

If you are interested in this project, please select Ruf as your group preference in the IPP application platform.

What we offer:

• Exciting, interdisciplinary projects in a fully international environment, with English as our working language
• Advanced training in scientific techniques and professional skills
• Access to our state-of-the-art Core Facilities and their technical expertise
• Fully funded positions with financing until the completion of your thesis
• A lively community of more than 190 PhD students from 44 different countries

Requirements:

Are you an ambitious, young scientist looking to push the boundaries of science while interacting with colleagues from multiple disciplines and cultures? Then the IPP is your opportunity to give your scientific career a flying start!

All you need is:

• Master or equivalent
• Interactive personality & good command of English
• 2 letters of reference

For more details on the projects offered and how to apply via our online form, please visit https://www.imb.de/phd

The deadline for applications is 8 November 2023. Interviews will take place at IMB in Mainz on 22-24 January 2024.

Starting date: 1 March 2024 – 1 August 2024

Thinking of doing your PhD in the Life Sciences? The International PhD Programme (IPP) Mainz is offering talented students the chance to work at the cutting edge of research. As an IPP PhD student, you will join a community of exceptional scientists working on diverse topics ranging from how organisms age or how our DNA is repaired, to how epigenetics regulates cellular identity or neural memory.

Activities and responsibilities:

In the field of “Epigenetics & Nuclear Dynamics”, the research group of Sandra Schick offers the following PhD project:

Genomic DNA is highly compacted into chromatin in order to fit into the nucleus of a cell. The packaging further provides a regulatory layer for DNA accessibility and therefore all DNA-dependent processes, such as transcription, DNA repair or replication. ATP-dependent chromatin remodellers can modulate the accessibility by moving or evicting nucleosomes. One class of these remodellers are the BAF complexes, very large multi-protein complexes existing in many different configurations in human cells. Their importance is highlighted by the fact that mutations in genes coding for these complexes are found in more than 20% of all human cancers and frequently causative for developmental diseases, especially several neurodevelopmental disorders. The molecular consequences of these mutations are hardly known so far. Therefore, understanding the cell type-specific composition and function of these complexes in the development of different organs as well as the cellular changes caused by the mutation of a subunit is of great importance for the development of therapeutics against these common BAF-mutated diseases.

PhD Project: Gene regulation by chromatin remodellers during development and disease

BAF complexes control the accessibility of cell type-specific genomic gene regulatory regions and are therefore of great importance for developmental processes, cell fate transitions during differentiation and cell maintenance. To understand their physiological role during human developmental processes and unravel disease-associated molecular alterations caused by mutations in genes encoding subunits of these complexes, we will implement stem cell differentiation into organoids combined with molecular perturbation tools such as CRISPR/Cas9 and chemically induced protein degradation. This will allow us to model developmental diseases and unravel the physiological role of the subunits/ BAF complexes in human developmental processes. With the help of bulk and single-cell genomics, proteomics, molecular biology, screening and imaging approaches, we will then dissect the cellular and molecular consequences upon loss of selected BAF subunits. This will provide novel insights into these diseases as well as the function of the BAF complexes and their subunits in developmental processes.

We are therefore looking for a highly motivated PhD student who is experienced in the lab, enthusiastic about science especially with regard to developmental processes, gene regulation and epigenomics and has a strong interest in tackling scientific questions in an interdisciplinary way. Computational skills are an asset but not compulsory.

If you are interested in this project, please select Schick as your group preference in the IPP application platform.

What we offer:

• Exciting, interdisciplinary projects in a fully international environment, with English as our working language
• Advanced training in scientific techniques and professional skills
• Access to our state-of-the-art Core Facilities and their technical expertise
• Fully funded positions with financing until the completion of your thesis
• A lively community of more than 190 PhD students from 44 different countries

Requirements:

Are you an ambitious, young scientist looking to push the boundaries of science while interacting with colleagues from multiple disciplines and cultures? Then the IPP is your opportunity to give your scientific career a flying start!

All you need is:

• Master or equivalent
• Interactive personality & good command of English
• 2 letters of reference

For more details on the projects offered and how to apply via our online form, please visit https://www.imb.de/phd

The deadline for applications is 8 November 2023. Interviews will take place at IMB in Mainz on 22-24 January 2024.

Starting date: 1 March 2024 – 1 August 2024

Thinking of doing your PhD in the Life Sciences? The International PhD Programme (IPP) Mainz is offering talented students the chance to work at the cutting edge of research. As an IPP PhD student, you will join a community of exceptional scientists working on diverse topics ranging from how organisms age or how our DNA is repaired, to how epigenetics regulates cellular identity or neural memory.

Activities and responsibilities:

In the field of “RNA Biology”, the research group of Marie-Luise Winz offers the following PhD project:

Proteins are central to any living organism. To protect cells from dysfunctional and toxic, disease-causing proteins formed by aberrant translation, eukaryotic translation quality control pathways detect translation defects and remove aberrant protein products, together with associated faulty mRNA blueprints and sometimes faulty ribosomal components. Many of those pathways rely on the recognition of ribosome collisions. Much is still unknown about the molecular mechanisms underlying translation quality control, and how these interact with other cellular machineries and with organismal health and life cycle. These are research objects in my group. Besides reporter systems and polysome profiling techniques, we use sequencing-based methods, most prominently UV crosslinking and analysis of cDNA (CRAC), to study RNA-protein interactions, translation and RNA modification in the context of translation quality control. These techniques provide a unique toolbox to approach our key questions:

1:           Which molecular interactions underlie translation quality control triggering and how are different targets distinguished?

2:           How does translation quality control interact with cellular stress responses, translation regulation and RNA modification?

3:           How does co-translational quality control work in neurons and does it change with ageing and disease?

4:           What is the role of translation quality control for RNA-based and RNA-targeted therapies?

With our RNA-centred research, we want to make fundamental contributions to the understanding of translation quality control and its links to age-related neurodegenerative diseases, to ultimately inform efforts to cure, prevent or delay the onset of such diseases.

PhD project: Option 1: New players in eukaryotic translation quality control

Our group has recently discovered a number of potential new players in translation quality control by collating published information from a range of different databases and studies. We are currently investigating the potential functions of several such players in budding yeast, to define in which processes these proteins are involved and what is their molecular mechanism, using, e.g., CRAC, as well as reporter-based analyses (Müller, Tollervey, and Winz, unpublished; Iyer and Winz, unpublished).

Our current efforts so far only cover a small number of potential candidates. In this project, further candidates will be identified from published data and will be screened by reporter systems, equally in budding yeast. Positively evaluated candidates will be further studied to reveal their role in translation quality control. In addition to evaluating candidates from published screens and databases, to reveal additional candidates, new, targeted screens will be explored, followed by similar screens and evaluations.

PhD project: Option 2: Translation quality control in gene-specific translation inhibition

General inhibitors of bacterial translation play an important role as antibiotics. On the other hand, in human translation, a handful of small molecules have recently been discovered that target biosynthesis of a specific protein by targeting either the mRNA or the nascent peptide. It is now well accepted that many unspecific translation inhibitors can cause ribosome collisions and thereby trigger translation quality control pathways.

In this project, we will investigate which role translation quality control plays in specific translation inhibition in mammalian cells.

If you are interested in one of these projects, please select Winz as your group preference in the IPP application platform.

What we offer:

• Exciting, interdisciplinary projects in a fully international environment, with English as our working language
• Advanced training in scientific techniques and professional skills
• Access to our state-of-the-art Core Facilities and their technical expertise
• Fully funded positions with financing until the completion of your thesis
• A lively community of more than 190 PhD students from 44 different countries

Requirements:

Are you an ambitious, young scientist looking to push the boundaries of science while interacting with colleagues from multiple disciplines and cultures? Then the IPP is your opportunity to give your scientific career a flying start!

All you need is:

• Master or equivalent
• Interactive personality & good command of English
• 2 letters of reference

For more details on the projects offered and how to apply via our online form, please visit https://www.imb.de/phd

The deadline for applications is 8 November 2023. Interviews will take place at IMB in Mainz on 22-24 January 2024.

Starting date: 1 March 2024 – 1 August 2024

Thinking of doing your PhD in the Life Sciences? The International PhD Programme (IPP) Mainz is offering talented students the chance to work at the cutting edge of research. As an IPP PhD student, you will join a community of exceptional scientists working on diverse topics ranging from how organisms age or how our DNA is repaired, to how epigenetics regulates cellular identity or neural memory.

Activities and responsibilities:

In the field of “Epigenetics & Nuclear Dynamics”, the research group of Stamatis Papathanasiou offers the following PhD project:

Proper division of the genomic material is fundamental for cell homeostasis. Although cells have developed a plethora of mechanisms to ensure error-free division, mistakes during mitosis are common in normal physiology and a hallmark in disease. Such mistakes give birth to dysbalanced, aneuploid genomes. A prominent manifestation of mitotic errors is the generation of abnormal nuclear structures, such as micronuclei and chromosome bridges, common features of nuclear atypia in cancer with major physiological significance. Micronuclei are miniature, additional nuclei that form when a chromosome lags during mitosis and then recruits its own nuclear envelope. These structures accumulate massive DNA damage and can lead to severe rearrangements by mechanisms that are now starting to be understood. Yet, we do not fully understand the effects of dysbalanced genomes on cellular function and how these abnormalities contribute to disease initiation and progression.

We recently discovered a new phenomenon of heritable chromatin and transcriptional defects mediated by micronuclei. These alterations are inherited after the micronuclei reincorporate into the normal nuclear environment of daughter cells and are strongly associated with long-lived DNA damage. This work showed that chromosomal instability is inherently coupled to variation in gene expression, which may impact tumor evolution and provided significant insight into the elusive mechanisms leading to non-genetic, cell-to-cell epigenetic variability observed in pathophysiology.

PhD project: Chromatin state dysregulation due to abnormal mitosis

Under what exact circumstances cell division errors can give birth to massive DNA lesions and other chromatin alterations, their inheritance in the progeny and their functional significance remain a mystery. The potential involvement of additional mitosis-mediated mechanisms – other than micronucleation – that initiate cascades of non-genetic alterations is also a black box.

We are excited to welcome a PhD candidate to attack these questions. We will combine cutting edge techniques, such as targeted chromosome manipulation and gene engineering, with the development of advanced systems to track mis-segregated chromosomes by live-cell imaging over multiple generations. We will identify additional sources of inherited abnormal nuclear structures, investigate their DNA damage/repair dynamics and determine the immediate and long-term effects on these nuclear bodies’ epigenome.

If you are interested in this project, please select Papathanasiou (CSD) as your group preference in the IPP application platform.

What we offer:

• Exciting, interdisciplinary projects in a fully international environment, with English as our working language
• Advanced training in scientific techniques and professional skills
• Access to our state-of-the-art Core Facilities and their technical expertise
• Fully funded positions with financing until the completion of your thesis
• A lively community of more than 190 PhD students from 44 different countries

Requirements:

Are you an ambitious, young scientist looking to push the boundaries of science while interacting with colleagues from multiple disciplines and cultures? Then the IPP is your opportunity to give your scientific career a flying start!

All you need is:

• Master or equivalent
• Interactive personality & good command of English
• 2 letters of reference

For more details on the projects offered and how to apply via our online form, please visit https://www.imb.de/phd

The deadline for applications is 8 November 2023. Interviews will take place at IMB in Mainz on 22-24 January 2024.

Starting date: 1 March 2024 – 1 August 2024

University of Cologne Faculty of Management, Economics and Social Science

Assistant Professorship in Investments (W1), no tenure track (f/m/d) (endowed by the Centre for Financial Research (CFR), Cologne)

The University of Cologne is one of the oldest and largest universities in Germany. With its six Faculties covering a broad spectrum of disciplines and its internationally outstanding research profile areas, it enjoys an excellent reputation for its academic achievements and high standards of undergraduate and graduate education. The position is based in the Faculty of Management, Economics and Social Sciences, which is consistently ranked among the top schools in research and teaching.

YOUR TASKS The successful candidate is expected to contribute to research and teaching in the Department of Finance with a strong focus on Investments, Asset Management, or related areas. Research should be targeted at top ranked international journals. The tasks of the professorship include training of students at all levels. The candidate should contribute to one of the faculty’s key research initiatives (https://wiso.uni-koeln.de/en/research/key-research-initiatives).

YOUR PROFILE We are seeking academics at an early career stage who have demonstrated their academic aptitude through outstanding research in their doctoral studies. Candidates for this position should have very good skills in empirical methods common in finance and should apply them to questions in Investments, Asset Management, or related areas. Publications in high-quality academic journals as well as teaching experience are desirable.

OUR OFFER The University of Cologne provides a stimulating academic environment with a wide range of career development opportunities as well as support services for dual career couples and family-friendly working conditions.

The professorship is endowed by the Centre for Financial Research, Cologne, and located in the Department of Finance. The successful candidate can draw on outstanding research facilities including a broad set of databases (https://wiso.uni-koeln.de/en/faculty/wisolibrary-and-campus-service/research-databases) and the international research network of the Centre for Financial Research (www.cfr-cologne.de). The professorship is endowed with an attractive research budget and a part time research and teaching assistant (0.75 E 13 TV-L). Administrative support is provided by the Office Manager of the Department of Finance.

The position (of a Juniorprofessorin / Juniorprofessor) is available as of 01. June 2024 (based on mutual agreement). Formal requirements are detailed in Section 36 of the Higher Education Act of North Rhine-Westphalia (Hochschulgesetz – HG NRW).

In the third year after entering into office, an interim evaluation is held. This serves as the basis for the decision as to whether an extension for a further three years will be granted to the candidate. W1 professorships comprise a teaching load of four hours per week (i.e., two hours per week is one 90-minute course per semester) in the first qualification phase and five hours per week in the second qualification phase.

The University of Cologne is committed to equal opportunities and diversity. Women are especially encouraged to apply and will be considered preferentially in accordance with the Equal Opportunities Act of North Rhine-Westphalia (Landesgleichstellungsgesetz – LGG NRW). We also expressly welcome applications from people with disabilities / special needs or of equal status.

Please submit your application (without a photo) via the University of Cologne’s Academic Job Portal (https://professorships.uni-koeln.de) by 04.10.2023. Your application should be addressed to the Dean of the Faculty of Management, Economics and Social Science. It should consist of the following documents (in English language): cover letter, curriculum vitae including a list of publications and current research projects. If available, the most important publications or working papers, and teaching evaluations should be added as well. For further information, please contact Prof. Dr. Alexander Kempf (kempf@wiso.uni-koeln.de).

he International Max Planck Research School for Elementary Processes in Physical Chemistry (IMPRS-EPPC) at the Fritz Haber Institute of the Max Planck Society offers

5 PhD Positions in Physical Chemistry

The Fritz Haber Institute (FHI) in Berlin-Dahlem is one of the oldest and renowned research institutes within the Max Planck Society (MPG), Germany's most successful scientific organization for fundamental research. At the FHI, researchers from all over the world are engaged in basic research in the field of chemical physics at interfaces and surfaces, catalysis research and molecular physics.

The graduate school IMPRS-EPPC in Berlin is offering 5 PhD positions for research projects to be carried out with any of the participating research groups at the FHI, the Freie Universität Berlin, Humboldt-Universität zu Berlin, Technische Universität Berlin, and Universität Potsdam. The positions are linked to membership in the IMPRS-EPPC, and will be co-funded between the IMPRS-EPPC and the respective research groups. The IMPRS-EPPC is a graduate school funded by the MPG and hosted at the FHI in Berlin. The research within the School focuses on understanding the elementary process steps in physical chemistry problems, ultimately leading to functionality, ranging from single molecules chemistry on surfaces or in the gas phase to ultrafast surface dynamics and complex catalyst performance. All departments of the FHI as well as expert groups from physics and chemistry of all Berlin and Potsdam universities channel their respective efforts under the roof of the IMPRS-EPPC. For details see: https://www.fhi.mpg.de/imprs/research

Research Projects:

Candidates should propose a specific research project in Physical Chemistry and related fields, to be carried out with any of the participating research groups, see: https://www.fhi.mpg.de/imprs/PIs

Your application:

Applications will be accepted only through the Online Application form. The application deadline is Oct 31 2023. Highly motivated applicants should hold an excellent Master’s degree or equivalent in physics, chemistry, material science or related fields. For details of the application requirements please see: https://www.fhi.mpg.de/imprs/application We thank all applicants for their interest; however, only those individuals selected for an interview will be contacted.

Funding:

The position is initially limited to three years (extension possible) with a starting salary corresponding to a 66,67% TVöD/E13, Level 1, position. The positions will be co-funded between the IMPRS-EPPC (1st year) and the respective research group (remainder of the contract).

For more information please visit our website at https:// fhi.mpg.de/imprs or contact us: IMPRS-EPPC, Fritz-Haber-Institut der Max-Planck-Gesellschaft Faradayweg 4-6, 14195 Berlin, Germany e-mail: imprs@fritz-haber-institut.de Phone: +49-30-8413-5102

The Max Planck Society is committed to increasing the number of individuals with disabilities in its workforce and therefore encourages applications from such qualified individuals. Furthermore, the Max Planck Society seeks to increase gender diversity in research and therefore explicitly encourages women and non-binary people to apply.