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Aging is the most robust risk factor for cancer development, with more than 60% of cancer incidence occurring in those aged 65 and above. Despite this, both the pre-clinical research that leads to the identification of and the clinical trials that lead to approval of anti-cancer drugs by the FDA largely overlooks the role of the aging process in cancer.
As the organism ages, cells lose their ability to function or begin to function abnormally throuout the body; byproducts and waste molecules build up in circulation and within tissues, connective tissue changes and becomes stiffer conditioning blood flow and oxygen intake, damage to building blocks of a cell (e.g. DNA, proteins, lipids) accumulate. Thus, as a whole an old organism is a different molecular entity than a young one, and tumors developing in aged hosts evolving in different ways than tumors developing in young ones its corollary. Recent work by Dr. Gomes has provided proof for this concept by demonstrating that treatment of established cancer cells with old human serum is sufficient to promote aggressive properties and propensity to metastasize (Gomes et al., Nature 2020). This puts the aging process at the center stage of tumorigenesis coordinating the different aspects required for the evolution of malignant phenotypes.
Research in the Gomes Laboratory at H. Lee Moffit Cancer Center, Tampa, FL is centered around this new paradigm: that tumor progression and drug resistance are shapped by the global deregulation of the aged host. Ultimately the overarching goal of the Gomes lab is to establish a framework for cancer that accounts for the organismal reprogramming that occurs with aging to allow for the development of more efficacious and age appropriate therapeutic strategies. To learn more about the Gomes lab visit our lab website at http://lab.moffitt.org/gomes.
Position Highlights:
- Joining a new field of research with many opportunities to grow within the field
- Utilizing cutting-edge technologies (e.g., single cell analyses, metabolomic/proteomics) as platforms of discovery
- Working within a multidisciplinary team (emcompassing immunologists, bioinformaticians, tumor biologists and clinicians) with plenty of room to learn new skills
- Moffitt integrates excellent patient care with cutting-edge clinical and basic research. Having a cancer hospital on-site provides unique opportunities for translational research.
- Working closely with Dr. Gomes on the postdoctoral fellow’s career development (e.g., grant/manuscript writing, scienfitic presentations, networking)
The Ideal Candidate:
- Independent and highly motivated with a proven track record of scientific productivity
- Excellent communication skills and ability to work collaboratively in a team
- Experience with immunology and/or single cell analyses is highly desirable
- Experience with mouse models of cancer is also highly desirable
Responsibilities:
- Work independently and collaboratively for the mission of the lab
- Design and execute experiments; analyse and interpret data
- Regularly present findings to the lab and to the Moffitt community
- Attend and present findings to the scientific community in conferences
- Mentor and train graduate and undergraturate students
- Write manuscripts, postdoctoral fellowships and assist with other funding applications
Credentials and Qualifications:
- MD or PhD, preferably not received more than two years ago
How to Apply:
Interested applicants should send a single PDF file that includes a cover letter summarizing their research training and accomplishments, scientific interests and career goals, current CV with publication record, and contact information for three references to Dr. Ana Gomes at ana.gomes@moffitt.org
Moffitt Cancer Center and Research Institute is proud to be Florida’s only National Cancer Institute-designated Comprehensive Cancer Center. We strive to be the leader in understanding the complexity of cancer through team science and applying those insights for human benefits. Every Team Member of Moffitt focuses on our lasting commitment to our mission: To contribute to the prevention and cure of cancer.
You will be eligible for benefits offered to our Team Members – Medical, Dental, Vision, Paid Time Off, Retirement, Parental Leave and more. With a move to Tampa, you may be eligible for relocation allowance. Reason to relocate, aside from the sunshine, beaches and year-round outdoor recreation associated with the Gulf Coast of Florida, Tampa is a thriving metropolitan city with unique cultural attractions, low cost of living and a high quality of life. We strive for work/life balance.
If you have the vision, passion, and dedication to contribute to our mission,
then we have a place for you.
Equal Employment Opportunity
Moffitt is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, or protected veteran or disabled status. Moffitt seeks candidates whose skills, and personal and professional experience, have prepared them to contribute to our commitment to diversity and excellence.
