We are hiring a Postdoctoral Associate in the Lester and Sue Smith Breast Center at Baylor College of Medicine. The Breast Center is a collaborative environment dedicated to breast health and disease research, as well as prevention, diagnosis, and treatment of different forms of breast cancer. We are looking for a candidate with a background in computational biology/bioinformatics who thrives in collaborative research.  For more information, visit https://www.bcm.edu/people-search/qian-zhu-119781

Job Duties

• Works in a Cancer Prevention & Research Institute of Texas (CPRIT) funded laboratory focused on computational cancer biology.
• Integrates various modalities of single-cell sequencing data and spatial genomics data to better understand the contribution of spatial multi-cellular environments to cancer formation, progression, and treatment.
• Contributes to the development of new methods or in the advancement of biological knowledge.
• Focuses on one of following:
  • Methodological development: The candidate will develop innovative methods to integrate multiple modalities of single cell data to disentangle cell-to-cell variability, and identify novel cell subpopulations that contribute to treatment resistance and cancer recurrence. Methods range from statistical, computational, to machine-learning based. These new methods are expected to benefit the community at large by being broadly applicable to different datasets.
  • Applied computational biology: The candidate will use a range of bioinformatics tools to analyze research data in order to glean interesting mechanistic insights during development and cancer progression, and treatment resistance. The candidate is expected to have excellent collaborative skills as he/she is expected to work alongside biologists and clinicians from other laboratories to make impactful discoveries.

Minimum Qualifications

• MD or Ph.D. in Basic Science, Health Science, or a related field.
• No experience required.

Preferred Qualifications

• Needs to have published a first-authored paper in a peer-reviewed journal.
• For candidate in the applied computational biology:
  • Knows how to use InferCNV to disentangle copy number variations in cancer genomics data.
  • Knows how to use Seurat, Monocle, SCENIC, Dynamo, Velocyto to infer both discrete cell populations and continuous developmental trajectories from single cell RNAseq data.
  • Knows how to infer cell-cell communication pairs.
  •  Knowledge about how to use UK Biobank and All of Us Research data is a plus.
  • Knowledge about genetic analysis, such as variant calling, is a plus.
• For candidates in the methods development area:
  • Knowledge of probabilities and statistics, probabilistic modeling, Bayesian network, and deep programming knowledge of Python, R, is required.
  • Deep learning related experience is a plus.
  • The candidate needs to demonstrate ability to implement new algorithms in Python, R, and modify existing implementations written in one of the these languages.

We seek two postdoctoral fellows to join the Mustelin/Najjar lab in the Rheumatology division, University of Washington, Seattle, USA, to lead and collaborate on genomics research projects in systemic autoimmune diseases. These are full-time positions on an annual service period of 12 months (July 1 – June 30).  The anticipated start date for these positions is July, 1st 2024.

The fields of autoimmunity and rheumatology have seen important advances in therapeutics that have improved patients’ lives. At the same time, all these advances are based on inhibiting inflammatory molecules that are physiologically important for a healthy immune system. We are interested in the next generation of therapeutics that will be personalized and only target the original disease process. Such treatments can only be created if we reveal the true causes of systemic autoimmune diseases.

Join our lab to help generate and test novel hypotheses in rheumatologic autoimmune diseases. We are looking for highly motivated postdoctoral fellows with expertise in computational biology, bioinformatics, or a similar field. While our lab conducts both wet and dry lab experiments, the current roles will focus on computational research. Our work explores multiple domains of biology including alternative splicing, transposable elements, and innate immunity sensing. Our research projects include analyses of multiple types of genomic data including bulk and single cell transcriptomics, spatial transcriptomics, epigenomics, and DNA sequencing.

The base salary range for this position will be $5,705-$6,000 per month, commensurate with experience and qualifications, or as mandated by a U.S. Department of Labor prevailing wage determination.

Postdoctoral scholar are represented by UAW 4121 and are subject to the collective bargaining agreement, unless agreed exclusion criteria apply. For more information, please visit the University of Washington Labor Relations website.

Qualifications

The ideal candidates will have PhDs (or foreign equivalent) in computational biology, bioinformatics, genomics, or other similar fields such as biostatistics. Applicants must have a proven publication record and a computational background is required.

Postdocs will lead projects in rheumatologic autoimmune disease and contribute to other projects on a collaborative basis.

Application Instructions

Please email Dr. Rayan Najjar (najjar@uw.edu) (1) a 1-page cover letter describing your computational experience, career objectives and research interests, (2) a CV with a list of publications (max. 3 pages), and (3) a list of three references. Please also apply at this link: https://apply.interfolio.com/144815

Equal Employment Opportunity Statement

University of Washington is an affirmative action and equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, creed, religion, national origin, sex, sexual orientation, marital status, pregnancy, genetic information, gender identity or expression, age, disability, or protected veteran status.

Benefits Information

A summary of benefits associated with this title/rank can be found at https://hr.uw.edu/benefits/benefits-orientation/benefit-summary-pdfs/. Appointees solely employed and paid directly by a non-UW entity are not UW employees and are not eligible for UW or Washington State employee benefits.

Commitment to Diversity

The University of Washington is committed to building diversity among its faculty, librarian, staff, and student communities, and articulates that commitment in the UW Diversity Blueprint (http://www.washington.edu/diversity/diversity-blueprint). Additionally, the University’s Faculty Code recognizes faculty efforts in research, teaching and/or service that address diversity and equal opportunity as important contributions to a faculty member’s academic profile and responsibilities (https://www.washington.edu/admin/rules/policies/FCG/FCCH24.html#2432).

Privacy Notice

Review the University of Washington Privacy Notice for Demographic Data of Job Applicants and University Personnel to learn how your demographic data are protected, when the data may be used, and your rights.

Disability Services

To request disability accommodation in the application process, contact the Disability Services Office at 206-543-6450 or dso@uw.edu.

We currently have multiple postdoctoral fellowship positions within the multidisciplinary research team headed by Dr. Ajay Goel, professor and founding chair of the Department of Molecular Diagnostics and Experimental Therapeutics and associate director of basic sciences at City of Hope Comprehensive Cancer. Our multidisciplinary research group comprises basic researchers, gastroenterologists, surgeons, oncologists, and bioinformaticians, undertaking several collaborative projects involving large international consortia. Our research is focused on translational research on the genomic and epigenomic characterization of various gastrointestinal cancers (GI), including colorectal, pancreatic, gastric, esophageal, and hepatocellular cancers. Our group performs cutting-edge research in GI oncology, is very productive, and publishes in high-impact journals such as Gastroenterology, Cancer Cell, PNAS, JAMA Oncology, JNCI, Clinical Cancer Research, Nature Communications, Nature Reviews Gastroenterology and Hepatology, Annals of Surgery, etc.

Some of the key research topics in our laboratory include:

1. Development of cell-free DNA (mutation and methylation), RNA, and exosomal-based liquid assays for early cancer detection, prognosis, and predictive responses to chemotherapies and targeted drugs.
2. Study the genetic and epigenetic basis of GI cancers (e.g., aberrant DNA methylation, histone modifications, and non-coding RNAs).
3. The genetic basis of early-onset colorectal cancer (EO-CRC) and familial/hereditary colorectal cancer.
4. The role of extracellular vesicles/exosomes in cancer pathogenesis and their role as disease biomarkers.
5. The role of the tumor microenvironment, stem cells, immune regulation, and identification of novel targeted therapies.
6. Cancer preventive and adjunctive role of natural and integrative therapy approaches.

Key Responsibilities include:

• Devise, plan, document, and advance basic science and translational projects in genetics, epigenetics, and precision oncology of gastrointestinal cancers.
• Generate data for grant applications and prepare manuscripts for publication.
• Work closely with other team members and external collaborators, including presenting progress internally or externally.
• Ability to work in a fast-paced team environment and handle multiple projects simultaneously.
• Train and supervise technical staff.

Qualifications: Basic education, experience, and skills required for consideration:

• Ph.D., MD, or MD/Ph.D., with a strong background and profound knowledge in oncology, cancer biology, immunology, or immunotherapy.
• Ability to work in a fast-paced research environment and manage multiple projects and collaborations.
• Previous experience working with human specimens and developing novel, innovative cancer biomarkers.
• Evidence of scientific rigor and excellence as documented by high-impact peer-reviewed publications.
• Strong team player with excellent communication skills and fluency in spoken and written English.
• The individual must have effective skills in oral and written communication, teamwork, and problem-solving and be adaptable to changes in technological and scientific directions
• Commitment to the program for at least 2-3 years.

Additional Information:

• You will have the unique possibility to drive research towards a novel cancer therapy at the interface of science and translation to the clinic and publish high-impact journals.
• Please send your current CV/resume to ajgoel@coh.org, along with a cover letter highlighting your research accomplishments, a brief statement explaining how your past research ties in with the goals of our laboratory, and future career plans.

Your application should include the following in a single PDF:

• Curriculum Vitae and coordinates of three scientific mentors or references
• A cover letter highlighting your research interests, a brief statement explaining how your past research ties in with the goals of our laboratory, and future career plans.

The City of Hope is committed to creating a diverse environment and is proud to be an equal-opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with a disability.

Our mission is to accelerate major scientific discoveries and engineering breakthroughs for humanity by designing and providing world-leading computing facilities in partnership with the computational science community. We help researchers tackle some of the world’s largest and most complex challenges with our unique combination of supercomputing resources and computational science expertise.

Our applied mathematics group is seeking a Postdoctoral Appointee to conduct research and development on differentiable and portable linear solvers tailored for advanced numerical simulations. This role will require the postdoc to work within a multi-disciplinary setting, facilitating interactions with a diverse range of experts across a broad spectrum of scientific computing, including HPC, automatic differentiation, and optimization. You will be expected to present and publish their findings at leading scientific symposia and in prestigious journals, contributing to the advancement of scalable and efficient computational methods.

Position Requirements

Required skills and qualifications:

• A recent or soon-to-completed Ph.D. (within the last 0-5 yes) in computational science with a focus on linear solvers.
• Software development skill in programming languages such as C,C++, and Julia. Experience in GPU programming.
• Effective written and oral communication skills.
• Ability to model Argonne's core values of impact, safety, respect, integrity and teamwork.

Desired skills and qualifications:

• Experience with automatic differentiation and generation of derivatives.
• Experience with machine learning methods.

Job Family

Postdoctoral Family

Job Profile

Postdoctoral Appointee

Worker Type

Long-Term (Fixed Term)

Time Type

Full time

A Postdoctoral position is available in the lab of Dr. Jun Yang in the Department of Surgery at St Jude Children’s Research Hospital (https://www.stjude.org/directory/y/jun-yang2.html).

The Yang lab focuses on understanding how epigenetic regulators co-opt with oncogenic transcription factors to drive tumorigenesis, cancer progression and metastasis, and therapeutic resistance. His lab also actively involves drug discovery to target the epigenetic modifiers. We apply cutting-edge technologies, such as single-cell multi-omics, spatial transcriptomics, CUT&Tag, genome-wide CRISPR in vivo screening, bioinformatics, and chemical biology approaches in multiple cancer model systems including genetic mice, PDX, and organoids.

We are seeking a Postdoctoral Associate whose research will study the functions of histone demethylases in solid tumors. Candidates with training background in molecular biology, cell biology, cancer biology, and cancer immunology are welcome to apply.

Minimum Qualifications

• Ph.D. in molecular biology, cell biology, cancer biology, and cancer immunology or a related field.
• No experience required.

Diversity, Equity and Inclusion

St. Jude Children’s Research Hospital has a diverse, global patient population and workforce, built on the principles of diversity, equity and inclusion. Our founder Danny Thomas envisioned a hospital that would treat children of the world—regardless of race, religion or a family’s ability to pay. Learn more about our history and commitment .

Today, we continue the mission to advance cures and means of prevention for pediatric catastrophic diseases through research and treatment. As we accelerate this progress globally, we believe our legacy of diversity, equity and inclusion is foundational to success. With the commitment of leaders at all levels of the organization, we strive to ensure the St. Jude culture, leadership approaches and talent processes are equitable and culturally responsive. View our Diversity, Equity and Inclusion Report  to learn about the hospital’s roots in diversity, equity and inclusion, where we are today and our aspirations for an even better future.

St. Jude is an Equal Opportunity Employer

No Search Firms

St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.