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- RESEARCH FIELD(S)1
Dynamic systems, molecular oscillators, ATP and GTP, biophysics, mathematics and computational biology, actin cytoskeleton
- JOB DESCRIPTION
Peyer’s patches are the main inductive sites of intestinal immunity, which is crucial for host defense against pathogens but also for regulation of the microbiota and tolerance to food proteins. Both right positioning and activation of specific immune cells are critical for the drastic change of transcriptional programs that lead to the initiation of the intestinal immune response. However, the links between immune cell location, their migration and interaction with neighboring cells, activation, transcriptional changes, and the immune response itself remain poorly characterized. Here, we will combine spatial transcriptomics, high resolution fluorescent imaging, bioinformatic analysis and cross-modal machine learning methods to decipher the microenvironmental circuits involved in Peyer’s patch immune response initiation in different conditions of stimulation. It will allow to understand how these different cellular mechanisms are orchestrated together to produce an appropriate immune response to detected threats.
- QUALIFICATIONS/SKILLS/EDUCATION & RESEARCH REQUIREMENTS
Good knowledge of single-cell RNA-seq analysis methods, differential expression calculations and functional enrichment. Basic knowledge of imaging analysis. Interest in biological questions, in particular in immunology and cell biology. Good organisational skills with synthetic presentation of scientific result and good communication with mathematicians, bioinformaticians and biologists.
- APPLICATION DEADLINE
February 16, 2022
- STARTING DATE
October 2022
- JOB LOCATION
Aix Marseille University at the Luminy Campus – Marseille
- REQUESTED DOCUMENTS OF APPLICATION
Application must include:
- CV
- cover letter
An email will be automatically sent to your two references in order for them to upload their recommendation letter directly. We invite you to contact them to make sure that they have received the email.
- CONTACT TO APPLY
