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- RESEARCH FIELD(S)1
Mucociliary epithelium, cilia, cell and tissue polarity, live imaging, image processing, metachronal waves, flow patterns, collective motion, active matter, Lattice Boltzmann simulations
- JOB DESCRIPTION
The purpose of this PhD project is to generate an experimental and theoretical framework to study cilia-driven fluid flow in vivo. The project brings together biology, physics and numerical simulation of fluid mechanics to understand how flows powered by beating cilia are organized to clean the surface of the amphibian Xenopus embryo. This animal model has generated extensive knowledge on fundamental parameters of ciliated epithelium biology, such as ciliated cell determination, cilia synthesis, and polarized beating. The PhD student will adapt light-sheet microscopy to image beating cilia in all cells of the mature embryo, so as to derive a global map of ciliated cell location and orientation (Teams 1 and 2). Special focus will be set on regions of complex topology (head, branchial arches, anal cavity), which deviate from the typical and simpler 2D organization studied so far. These experimental parameters will be used to feed Lattice Boltzmann-based simulation, with the aim of generating numerical paradigms to explain the emergence of metachronal ciliary beat waves and spatial flow patterns (Team 3). This work will help to understand how ciliated epithelium organization is modulated to fulfill its physiological role in a complex 3D organism.
- QUALIFICATIONS/SKILLS/EDUCATION & RESEARCH REQUIREMENTS
The selected PhD student must have a keen interest in interdisciplinary and quantitative approaches to study biological problems. The selected candidate is expected to be able to adapt light-sheet microscopy (commercial or custom systems) to the constraints of the Xenopus embryo. The ideal candidate should therefore have a strong taste for imaging and engineering, as well as for image processing. Candidates with a strong interest in modeling will be favorably considered.
- APPLICATION DEADLINE
February 16, 2022
- STARTING DATE
October 2022
- JOB LOCATION
Aix Marseille University at the Luminy Campus – Marseille
- REQUESTED DOCUMENTS OF APPLICATION
Application must include:
- CV
- cover letter
An email will be automatically sent to your two references in order for them to upload their recommendation letter directly. We invite you to contact them to make sure that they have received the email.
- CONTACT TO APPLY
