The Channing Division of Network Medicine, Brigham and Women’s Hospital, and Harvard Medical School are seeking applicants for 3 postdoctoral positions in integrative omic analysis of asthma, lung function, and aging. All projects provide a terrific opportunity to work with large, deeply-phenotyped human populations with a focus on the integrative multiomic analysis. The ideal candidate will have a strong background in programming or statistics together with a familiarity with bioinformatics tools. No wet lab or laboratory experience is desired or required. All projects are jointly supervised by Assistant Professor Michael McGeachie and Associate Professor Jessica Lasky- Su, or by Dr Lasky-Su alone, but it will also include interacting with a highly-interdisciplinary team of researchers from both the Channing and elsewhere in the Longwood Medical Area, Boston MA.

Project 1: The position will focus on the analysis of microRNA-Seq and metabolomics profiling data from a Biobank cohort with asthma, with additional integrative omic investigations including the integration of genomic variants and DNA methylation. We are specifically interested in studying miRNA and metabolomic influences on asthma progression through lung function, while including other omic datatypes including genetics, genomics and the microbiome. (Supervisors Drs McGeachie and Lasky-Su).

Project 2: The position will focus on the analysis of large-scale antibody profiling and metabolomics profiling data from a Biobank cohort with asthma, with additional integrative omic investigations including the integration of genomic variants and DNA methylation. Primary goals include studying infection and metabolomic influences on asthma progression through lung function and other disease outcomes, while including other omic datatypes including genetics, genomics and the microbiome. (Supervisor Dr Lasky-Su).

Project 3: The position will focus on the analysis of multi-omic data and electronic medical records (EMR) from several Biobank cohorts, with additional integrative omic investigations including the integration of genomic variants and DNA methylation. The main work will be studying aging and chronic disease trajectories, while integrating omic datatypes including metabolomics, proteomics, genetics, genomics and the microbiome. (Supervisor Dr Lasky-Su).

The Channing Division of Network Medicine represents a diverse and highly collaborative research community that is focused on deciphering the etiology of complex diseases. The lab benefits from active collaborations with computational, biostatistical, and networking experts. We also work with state-of-the-art laboratories for the generation of ‘omics’ data and have established bioinformatic pipelines for cleaning and preparing data for analysis. The fellow will primarily be working on the statistical analysis and scientific write up of projects based within one of our many well-established longitudinal cohorts of children and adults, which have a wealth of multi-omic data and cover lifestyle, behavior, dietary and environmental risk factors. These outstanding resources offer the potential for a high-quality candidate to address scientific questions of interest and to develop their

research career in a vibrant environment. We are seeking highly motivated and analytically-capable applicants who have a strong interest in progressing the field through impactful science.

QUALIFICATIONS: Applicants should have a Ph.D., Sc.D. or M.D. with a strong analytic background in genomics, bioinformatics, statistics, epidemiology, computer science, network biology or related field. Programming proficiency in some language is required (e.g. Java, C, C++, Python, Perl, SAS, MATLAB or R). Previous experience with analyzing metabolomic and/or next generation sequencing data is desired. Scientific publications in a peer-reviewed journal are necessary. Excellent written and verbal communication skills are essential.

To apply, please supply a cover letter describing current research interests and specifically addressing your interest in the work of the Channing and how your background may uniquely prepare you for one of the three projects. Applications should also include a CV including contact information for three references and mail to remmg@channing.harvard.edu and rejpo@channing.harvard.edu.

Brigham and Women’s Hospital is a Harvard Medical School affiliated institution, with over 1000 principal investigators. The Channing Division of Network Medicine is a research division within the Department of Medicine whose goal is to define the etiology and reclassify complex disease using network- and systems-based approaches. This group includes some of the largest population-based and pulmonary cohorts in the world, and an outstanding track record of mentoring.

We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, gender identity, sexual orientation, pregnancy and pregnancy-related condition or any other characteristic protected by law. Women and minority candidates are particularly encouraged to apply.

Appointment and/or employment at a Mass General Brigham affiliate is contingent upon compliance with all requirements for employment at the MGB affiliate. These requirements include without limitation: • United States Citizenship and Immigration Services rules concerning identity and right to work in the United States • Multi-state criminal background checks • Review of the Medicare Sanctions and Exclusions List • Pre-employment health and drug screening and annual compliance with the Influenza Vaccination Policy Any offer of employment is contingent upon satisfactory completion of the above requirements for employment, as well as satisfactory completion of the credentialing and medical staff appointment process at the MGB affiliate(s) where the applicant will provide clinical services. Reference information, including academic and/or employment records, final evaluations, and recommendations for future employment will be required.

The postdoc scholar will participate in several research projects pertinent to retinal diseases currently funded by the Dr. Gangaraju lab. This individual will also have the responsibility of carrying out independent research related to these projects.

PhD in Health Sciences not limited to Pharmacology, Biochemistry, Clinical and Experimental Therapeutics.

The candidate must have acquired a solid publication record (at minimum one first author) and have excellent laboratory skills. Strong verbal and written communication skills in English are required. Candidates should have experience with the techniques of protein biochemistry, cell culture, microscopy, and animal experiments. Candidates with experience in vision science are highly preferred.

Applicants should have a demonstrated commitment to and knowledge of equal employment opportunity and affirmative action.

The University of Tennessee Health Science Center is the flagship statewide, public, academic health institution in Tennessee. Founded in 1911, the mission of the University of Tennessee Health Science Center is to improve the health and well-being of Tennesseans and the global community by fostering integrated, collaborative, and inclusive education, research, scientific discovery, clinical care, and public service. Employing more than 4,600 people on its faculty, staff, and not-for-profit corporation faculty practice groups, and with more than 3,200 students across the state, UTHSC contributes $4 billion to the economy of Tennessee.

Part of the University of Tennessee System, the Health Science Center is headquartered in Memphis and includes all six of UT's doctoral-degree-granting health science colleges -- Medicine, Dentistry, Pharmacy, Nursing, Graduate Health Sciences, and Health Professions. UTHSC spans the state with its four major, regional clinical health science locations in Memphis, Knoxville, Chattanooga, and Nashville, as well as more than 100 clinical education sites across Tennessee. UTHSC is the largest educator of health care professionals in the state and operates the state's largest residency and fellowship advanced training programs.

Located in West Tennessee on the banks of the Mississippi River, Memphis is the second-largest city in the state and among the largest cities in the Southeast. The Greater Memphis metropolitan area has more than 1.3 million residents, and the city ranks among those with the lowest cost of living in the country. It is home to a vibrant restaurant scene, a revitalized Downtown, the Midtown Arts District, many scenic neighborhoods, an active medical district, and a burgeoning airport in the midst of a $214 million modernization.

Memphis boats attractions, including Elvis Presley's Graceland, the Memphis Grizzlies, historic Beale Street, the National Civil Rights Museum, the second-largest urban county park in the United States, and the Memphis in May World Championship Barbecue Cooking Contest.

Dr. Putluri's laboratory is dedicated to investigating cause role of cancer progression, with a particular focus on bladder cancer research. Our lab has established a robust research program in this field, encompassing the characterization of metabolic alterations associated with smoking in bladder cancer, exploring health disparities, and elucidating the role of xenobiotic metabolism in bladder cancer progression. We employ a diverse array of pre-clinical models including cancer cell lines, 3D spheroid cultures, orthotopic xenografts, patient-derived xenografts (PDXs), and genetically engineered mouse models (GEMMs). We are actively seeking a highly motivated Postdoctoral Associate who shares our passion for translational tumor research. For further insight into our work, please consider reading the most recent paper published by our laboratory (Nat Commun. 2024; PMID: 38355560).

Job Duties

• Prepares and conducts laboratory research experiments.
• Collects, compiles and analyzes data.
• Collaborates with scientists out of the lab for multidisciplinary study in cancer related projects.
• Develops new model and technique to support the cancer-related research in the lab.
• Documents experimental procedures in precise details.
• Collects and compiles imaging data.
• Assists in day-to-day operation of running scientific research lab.
• Attends Lab Meetings, documents weekly data and monthly data.
• Performs independent research in the field of cancer metabolism.
• The focus of our laboratory is cancer metabolism and tumorigenesis. The research work will involve a combination of metabolomics, genomics, epigenomics, shRNA KD, CRISPR-gene editing approaches, over expression and a variety of model systems including cell line, organoids, mice and PDXs.
• Seeks external funding via grants applications/submissions and organizes the data for grant submission.
• Conducts literature searches and summarizes information in an appropriate format for a particular study.
• Should write the IACUC, IRB and IBC reports and ensure these are kept updated.
• Performs sample extraction for metabolomics and use of mass spectrometry instrumentation needed for the projects (training will be provided as needed).
• Demonstrates competency in method development, execution, data analysis, and interpretation of metabolomics profiling and quantitative targeted assays.

Minimum Qualifications

• MD or Ph.D. in Basic Science, Health Science, or a related field.
• No experience required.

Preferred Qualifications

• Prior experiences in tissue culture and basic molecular biology techniques (e.g., PCR, DNA purification, Western blot, etc.).
• Experience with handling animal models including performing/maintaining therapeutic experiments using mouse models will be plus.
• Experience with LCMS or Cancer metabolism will be plus.

Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.

Université Trent

L'Université Trent lance un appel à candidatures pour un poste de professeur à durée limitée de trois ans (36 mois) en comptabilité à l'École de commerce au rang de professeur adjoint, à compter du 15 août 2024. L'École de commerce est à la recherche d'un chercheur exceptionnel possédant une expertise en comptabilité. Ce poste est situé au campus Peterborough de Trent et est sujet à l'approbation budgétaire.

L'Université Trent est l'université de premier cycle la mieux classée en Ontario, au Canada, avec une réputation d'excellence en enseignement et en recherche. L'École de commerce propose des programmes de premier cycle et des cycles supérieurs axés sur la recherche, pédagogiquement innovants et engagés dans la communauté à la faculté des sciences humaines et sociales de Trent. Le candidat retenu contribuera aux domaines de force de l’École en comptabilité. Des informations sur l'École de commerce sont disponibles à trentu.ca/business .

Les candidats doivent avoir un doctorat. (ou être sur le point d'être terminé à la date de nomination) en comptabilité. Un titre de CPA ou équivalent est un atout. Il s'agit d'un poste à forte intensité d'enseignement et les responsabilités comprendront la contribution à la prestation des cours et au développement du programme de l'École de commerce, ainsi que le développement d'un programme de recherche de haute qualité et la fourniture de services à l'École. Le candidat retenu doit avoir démontré une capacité d’excellence en enseignement de premier cycle. Le candidat retenu devra enseigner des cours de comptabilité financière et de gestion à tous les niveaux du programme de premier cycle BBA et du programme de maîtrise en gestion.

Les candidats qualifiés sont invités à soumettre leur candidature en format PDF par courriel à admnjobs@trentu.ca , en précisant « Comptabilité LTA » dans l'objet. Les candidatures doivent inclure une lettre de motivation et un curriculum vitae ; un énoncé de recherche et des exemples d'études significatives ; un portfolio d'enseignement comprenant un énoncé de philosophie d'enseignement et des preuves de l'efficacité de l'enseignement, telles que des programmes et un résumé des évaluations pédagogiques ; et les noms et coordonnées de trois (3) personnes familières avec la carrière universitaire du candidat qui peuvent être contactées pour soutenir la candidature. Les candidats peuvent également soumettre un formulaire d’auto-identification dans le cadre de leur dossier de candidature.                                                                                                        

L’examen des candidatures débutera le 24 avril 2024.

L’Université Trent s’engage à créer une communauté universitaire diversifiée et inclusive. Tous les candidats qualifiés sont encouragés à postuler ; cependant, les citoyens canadiens et les résidents permanents auront la priorité. La préférence sera accordée aux candidats issus de groupes sous-représentés, notamment les femmes, les peuples autochtones (Premières Nations, Inuits et Métis), les personnes handicapées, les membres de minorités visibles ou de groupes racisés et les personnes LGBTQ2+.

L'Université Trent offre des aménagements aux candidats handicapés dans ses processus de recrutement. Si vous avez besoin d'aménagements pendant le processus de recrutement ou si vous avez besoin d'une version accessible d'un document/d'une publication, veuillez contacter schoolofbusiness@trentu.ca .

Bien que tous les candidats soient remerciés pour leur intérêt et leur candidature à ce poste, seules les personnes sélectionnées pour une entrevue seront contactées. 

Pour plus d'informations sur ce poste, veuillez envoyer un courriel à Byron Lew, directeur, École de commerce, bloww@trentu.ca .