As of January 2022 the research group “Molecular Interventions in the Cardivascular System” headed by Prof. Dr. Christian Kupatt in the Department for Internal Medicine I of the Klinikum rechts der Isar Hospital of Munich Technical University is looking for

The research project offering the doctorate aims at gene editing of hereditary heart disease. For this purpose, the AAV-vector based gene editing application to the heart will be studied in a variety of small and large animal models. In vitro assays and detailed analysis of molecular signaling factors crucial for the achievement of correction of genetic mutation by Cas9-based gene editors will be pursued, before using the most attractive candidates in vivo in murine and porcine hearts. In doing so basic science is integrated with translational research.

• As part of the large animal team, you contribute to design, preparation and conduction of large animal experiments focusing on gene editing of heart failure phenotypes
• Systemic analysis of tissues by molecular and histological methods will be an essential part of your scientific work

• Approbation as a veterinarian or physician or a master (or diploma) in (molecular) biology or biochemistry
• Strong interest in cardiovascular biology
• Experience or interest in molecular biology methods
• You have an above-average engagement and a genuine interest in science
• English writing

• An ERC-funded international research group in a well-equipped and scientifically stimulating surrounding with communicative atmosphere
• Comprehensive on-the-job training provided by experienced and qualified colleagues
• The opportunity to take part in internal and external professional development courses
• An opportunity to work in the city centre of Munich with good access to public transport systems and benefits in the form of specially discounted public transport tickets
• Performance-related salary in accordance with the TV-L public-sector salary scale plus attractive benefits offered to public-sector employees

If the candidates’ suitability for the position in question is equal, severely disabled applicants shall be given preference. Interview-related costs can, unfortunately, not be reimbursed.

Please submit your complete application documents containing

1. a letter of motivation and future perspectives,
2. CV,
3. certificates from college, bachelor, master degrees and
4. at least one personal certificate, preferably from the advisor of your Master thesis,

by e-mail quoting number 1439 to:

Prof. Dr. Christian Kupatt
Klinik und Poliklinik für Innere Medizin I
Klinikum rechts der Isar der Technischen Universität München
Ismaninger Straße 22
81675 München
E-Mail: christian.kupatt@tum.de