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A Postdoctoral Fellow position is available in the research team of Professor Gabor Tigyi laboratory, Department of Physiology, University of Tennessee Health Science Center. The postdoctoral fellow and research team will investigate the radiation protective mechanism of action of lysophosphatidic acid analogs. Specifically, we are interested in determining the regulation of signalosomes that are responsible for the augmentation of DNA repair and reduction of apoptosis elicited by the long-duration activation of the lysophosphatidic acid receptor 2. A particular focus of these studies is on the adapter protein encoded by the immediate-early gene product IEX-1. IEX-1 has the ability to form supramolecular complexes with the AKT and ERK1/2 kinases, inhibits the PP2A phosphatase and leads to activation of DNA-dependent Protein Kinase, which in turn promotes high-fidelity double-strand DNA repair in cells exposed to genotoxic stress. (Please read background references: Patil et al., PMID:25619933; Balogh et al. PMID 26027517, Kuo et al. PMID:30063964, Tigyi et al PMID:3069214
The postdoctoral fellow should have strong background and experience in biochemical techniques in molecular signaling and DNA repair. Experience using co-immunoprecipitation, Western blotting, immunohistochemistry, cell culture, transduction/transfection methods is required.
Qualifications:
PhD
Interested individuals should send CV to Professor Gabor Tigyi via email (gtigyi@uthsc.edu).
Salary will be commensurate with relevant experience and is competitive for postdoctoral fellows. The position includes an excellent benefits package (http://www.uthsc.edu/postdoc/benefits.php). Located in Memphis, a dynamic Mid-South city rich in culture, history, diversity, music and cuisine, the University of Tennessee Health Science Center is one of the largest, most comprehensive academic health centers in the United States with a solid commitment to postdoctoral training. UTHSC is an EEO/AA/Title VI/Title IX/Section 504/ADA/ADEA/V institution in the provision of its education and employment programs and services.
