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The University of Paris Saclay for the laboratory directed by Pr Laurence ZITVOGEL, located in Institut Gustave Roussy, Villejuif-Grand Paris, FRANCE is offering a 3 year-fully funded PhD fellowship, through the T-OP european program on CAR T cells and gut microbiota.
We are looking for a highly motivated candidate holding a master degree or equivalent in immunology, microbiology, biology, biochemistry, cell biology, molecular medicine or a similar program to join our T-OP funded research program.
Laurence Zitvogel group, UMR1015 research unit « Tumor Immunology and immunotherapy of cancer » is exploring the gut microbiota and its pro or anti -tumor immune functions. Bacteria modulate the antitumor efficacy in preclinical tumor models and clinical trials in cancer patients receiving conventional anticancer compounds and immunomodulators (Immune checkpoint inhibitors, immunogenic chemotherapy). These findings support the concept whereby bacteria-mediated interactions with the immune system are essential for optimal drug efficacy. Adoptive T cell therapy (ACT), that uses a patient’s own immune system to fight tumors, has recently been approved by medicines agencies in leukemia and lymphoma patients. Clinical trials of ACT for solid tumors are undergoing and this field is rapidly expanding.
The PhD student applicant will explore the role of the gut microbiota in modulating the efficacy of adoptive T cell therapy (CAR T cells / TCR modified cells), using a mouse model and human samples from patients undergoing ACT in Institut Gustave Roussy.
The position is offered for a period of 3 years. The starting date is from June 2021 to February 2022, according to the candidate availabilities.
The training network for optimizing adoptive T-cell therapy of cancer (T-OP) is an ambitious European program offering competitive PhD grant to high quality students/early stage researchers, which aims to improve efficacy and production of cell therapies and enables future experts to develop new therapeutic solutions. The ITN T-OP Training Network for Optimizing Adoptive T cell Therapy of Cancer is funded by the Marie Skłodowska-Curie program, H2020 with Grant Agreement no 955575.
Deadline for applications: 30th of April, 2021
Requirements:
– PhD student applicants must be in the first four years of research experience after completion of a Master’s degree or equivalent and cannot hold a doctoral degree (except medical doctor) at the time of the recruitment;
– The applicant cannot have spent more than 12 months within the past 36 months in France;
– The applicant must be proficient in the English language both written and spoken (proof required).
Application procedure:
The two-stage application procedure will be carried out in compliance with the Code of Conduct for Recruitment and the Charter for Researchers.
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- The first stage consists of sending your documents and filling out the required information within the application portal of T-OP, https://www.portal.graduatecenter.uni-muenchen.de/ocgc/t-op , by Friday April 30th, 2021. Please note that we will only evaluate fully completed application forms that are submitted via the application portal of T-OP before the deadline.
- Second stage: Selected candidates from the first stage will be invited for interview, possibly remotely, with the supervisor of the position for which the candidates have applied.
Applications should be submitted online within the application portal of T-OP: https://www.portal.graduatecenter.uni-muenchen.de/ocgc/t-op .
For more information about T-OP: www.itn-top.eu
