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Position Title: Research Associate
Hiring Unit: Department of Physiology, Faculty of Medicine
Supervisor: Dr. John Hanrahan
Work Location: McIntyre Medical Sciences Building, McGill University
Hours per week & Working Schedule: 40 hours/week, 9:00 – 6:00
Hourly Wage: $27.18 – $38.42 (salary commensurate with experience)
Planned Start Date & End Date of appointment: TBD
Date of Posting: March 30, 2020
Deadline to Apply: May 8, 2020
PRIMARY DUTIES
The Hanrahan Laboratory in the Department of Physiology in the Faculty of Medicine at McGill University seeks a Research Associate available to join the CF Translational Research Centre (CFTRc).
The applicant will carry out a research project on the role of sphingolipids and specifically ceramides in airway physiology and cystic fibrosis.
Responsibilities:
- Study novel mechanisms of CFTR regulation by membrane lipids and the impact of CFTR on intracellular and extracellular pH, bicarbonate and proton secretion, and the roles of surface liquid pH in antimicrobial activity and mucociliary transport.
- Develop micro-methods for studying pH, design experimental protocols that involve fluorescence imaging and electrophysiological measurements, and will be expected to drive this project and break new ground.
- Requires decision-making and the ability to troubleshoot problems in the laboratory, resolve conceptual problems in experimental design, and interpret results in the context of mathematical models.
- Analyze data, review and evaluate the findings.
- Prepare written and oral reports and manuscripts for publication.
- Assist in preparation of grant proposals.
- Presenting results at scientific meetings and will represent the lab and the CFTRc at internal and external meetings and conferences.
- Participate is the supervision of a graduate student and an undergraduate student. Also will be training users in ratiometric fluorescence imaging and other techniques.
EDUCATION/EXPERIENCE: PhD in Physiology or Biophysics
OTHER QUALIFYING SKILLS & ABILITIES:
- The candidate must be able to work independently and also collaborate with other members of the laboratory.
- Experience with ratiometric fluorescence imaging for intracellular pH, experience with buffers and microtitrations, patch clamp recording of CFTR, and expertise with gas mixing pumps.
- A basic understanding of lipid metabolism and in depth understanding of pH and buffer capacity is essential.
- Experience with mammalian cell culture at the air-liquid interface is essential.
HOW TO APPLY:
Please submit your application to:
Applicants should submit a cover letter explaining their qualifications and their interest in this position, a curriculum vita and the names and contact information for three individuals who could provide letters of recommendation. Applications and all inquiries should be sent to Dr. John Hanrahan via e-mail to john.hanrahan@mcgill.ca.
McGill University is committed to equity in employment and diversity. It welcomes applications from indigenous peoples, visible minorities, ethnic minorities, persons with disabilities, women, persons of minority sexual orientations and gender identities, and others who may contribute to further diversification.
“All qualified applicants are encouraged to apply; however, in accordance with Canadian immigration requirements, Canadians and permanent residents will be given priority.”
