Postdoctoral Research Scientist – Columbia University Irving Medical Center

The laboratory of Dr. Andrew R. Marks, Chair, Department of Physiology and Cellular Biophysics at Columbia University Irving Medical Center, is seeking 3 Postdoctoral Research Scientists (see Markslab.org). Projects include: cryo-EM structures of RyR channels, calcium signaling in cardiovascular, metabolic and neurodegenerative disorders. We are translating fundamental discoveries into ongoing clinical trials. Recent laboratory members have gone on to leading academic and pharmaceutical industry positions.

Selected publications include:

Liu, X., Betzenhauser, M.J., Reiken, S., Meli, A.C., Arancio, O., Chen B.-X., Marks AR (2012) Role of Leaky Neuronal Ryanodine Receptors in Stress-Induced Cognitive Dysfunction Cell 150, 1055–1067.

Ran Zalk, Oliver B. Clarke, Amédée des Georges, Robert A. Grassucci, Steven Reiken, Filippo Mancia, Wayne A. Hendrickson, Joachim Frank, Marks, A.R. (2014) Structure of a mammalian ryanodine receptor Nature 2015 517(7532):44-9.

Waning DL, Mohammad KS, Reiken S, Xie W, Andersson DC, John S, Chiechi A, Wright LE, Umanskaya A, Niewolna M, Trivedi T, Charkhzarrin S, Khatiwada P, Wronska A, Haynes A, Benassi MS, Witzmann FA, Zhen G, Wang X, Cao X, Roodman GD, Marks AR, Guise TA Excess TGF-Beta mediates muscle weakness associated with bone metastases in mice. Nature Medicine, 2015 Nov;21(11):1262-1271.

des Georges A, Clarke OB, Zalk R, Yuan Q, Condon KJ, Grassucci RA, Hendrickson WA, Marks AR, Frank, J Structural Basis for Gating and Activation of RyR1. Cell 2016 Sep 22;167(1):145-157

Melville Z, Kim K, Clarke OB, Marks AR. High-resolution structure of the membrane-embedded skeletal muscle ryanodine receptor. Structure. 2021 Aug 26:S0969-2126(21)00296-3. doi: 10.1016/j.str.2021.08.001. Online ahead of print. PMID: 34469755

Competitive salaries and potential positions on our NIH funded T32 training grants available.

Qualifications

All applicants should have a PhD or MD/PhD, outstanding publications, oral and written communication skills, organizational skills, work ethic, and the ability to work independently.

Application Instructions

All applicants must apply online.

Please email a curriculum vitae and contact information for three references to: Dr. Andrew R. Marks andrewmarksoffice@cumc.columbia.edu

Equal Employment Opportunity Statement

Columbia University is an Equal Opportunity Employer / Disability / Veteran