We are offering a 2-year postdoc position in the group of Dr. Marco Marcia (https://www.embl.org/groups/marcia/) at the European Molecular Biology Laboratory (EMBL), one of the highest-ranked scientific research organizations worldwide. The group is based in Grenoble, France.
We are carrying out an exciting project that will decipher the molecular mechanism of a human long non-coding RNA (lncRNA) involved in cancer, development, and infection diseases. Examples of recent work of the lab in the field are: Uroda et al, Mol Cell 2019 (doi: 10.1016/j.molcel.2019.07.025) and Uroda et al, Nat Prot 2020 (doi: 10.1038/s41596-020-0323-7).
The project will be conducted in close partnership with the teams of Dr Andre Verdel and Pr Pierre Hainaut at the Institute of Advanced Biosciences in Grenoble (IAB; https://iab.univ-grenoble-alpes.fr/), under the framework of a well-established joint institutional collaboration.
You will contribute to characterize how lncRNA MEG3 stimulates the p53 pathway acting as a tumor suppressor. Benefiting from experimental protocols established in the lab, you will be able to gain interdisciplinary training and combine cellular functional approaches (i.e. gene reporter and flow cytometry assays) with interactome studies (proteomics, genomics, transcriptomics) and biochemical, biophysical and structural biology experiments (including cryo-EM).
Through EMBL and IAB, you will have direct access to state-of-the-art light microscopy, flow cytometry, proteomics, genomics, and transcriptomics facilities and relative training and supervision to acquire or strengthen your expertise in these fields (https://www.embl.org/services-facilities/). You will also have on site direct access to T12, Glacios and Titan Krios transmission electron microscopes, to synchrotron beamlines, all state-of-the-art biophysical equipment (see https://www.psb-grenoble.eu/), and bacterial, insect, and mammalian cell culture facilities.
You will also participate in regular group meetings, departmental progress reports, and sharing of lab responsibilities.
You should hold or be about to obtain a Ph.D. in biochemistry, molecular, cellular biology or related fields. Proven previous experience in working with large RNAs and RNA-protein complexes either from a structural or from a cellular biology perspective would be a plus.
You should also be motivated to work in a multidisciplinary and international environment. A preference will be given to candidates that are committed and qualified to secure independent postdoctoral funding.
Why join us
EMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to an international research organisation with a very collegial and family friendly working environment. The remuneration package comprises from a competitive salary, a comprehensive pension scheme, medical, educational and other social benefits, as well as financial support for relocation and installation, including your family. Please note that appointments on fixed term contracts can be renewed, depending on circumstances at the time of the review.
What else you need to know
Please, submit a cover letter and your CV, including a list of your publications, and the name and contact addresses of at least two referees.
The position can be filled immediately, but the start date can be discussed. Applications will be considered on a rolling basis, as soon as submitted, and until the position is filled.
Informal inquires can be addressed to Dr. Marco Marcia directly (firstname.lastname@example.org).
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