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Portugal
Posted 1 year ago

CUBE - Católica Lisbon Research Unit in Business and Economics at Católica Lisbon School of Business & Economics, Universidade Católica Portuguesa, is awarding a one Research Fellowship (BI) in the scientific field of Economics/Applied Economics, for the development of research in the frame of the project PTDC/EGE-ECO/7844/2020 entitled “Adjusting to Crisis: Impacts, Channels and Policies”, with the financial support of FCT - Foundation for Science and Technology, I.P. (FCT, IP) / MCTES through national funds (PIDDAC).

WORK PLAN AND GOALS The selected candidate will conduct academic research in the field of Economics, with a strong quantitative component. The main duties of the researcher include: • Develop and carry out theoretically informed and empirically grounded research focusing on the project topics described above; • Manage large datasets, particularly for longitudinal microdata, such as “Quadros de Pessoal”; • Perform statistical analysis and econometric analysis of the data using appropriate software (Stata, R); • Carry out and develop collaborative research with other project colleagues and research groups; • Prepare academic papers and presentations; • Contribute to the organization of project events and activities (e.g. seminars, workshops) in collaboration with “PROSPER - Center of Economics for Prosperity” research center.

ADMISSION REQUIREMENTS • At the time of the application, candidates must be holders of an Undergraduate degree in the scientific field of Economics or related scientific fields, and be enrolled or present proof of meeting the requirements to be enrolled in a master’s program in the referred scientific areas; • In the case of candidates who are enrolled or who meet the conditions for the enrollment in a course that does not award an academic degree, only candidates who do not exceed, with the conclusion of the fellowship contract referred to in this notice, including the planned renewals, a cumulative period of two years in this type of fellowship, consecutive or interpolated, are eligible. The following skills are required: • Strong skills in Applied Economics; • Good data collection and data analysis skills and ability to work in statistical software such as Matlab, STATA, Python or R; • Ability to work in a team as well as independently; • Written and spoken proficiency in English.

FELLOWSHIP’S DURATION AND START DATE The fellowship will be awarded for a period of 03 months, in exclusive commitment. The fellowship may be renewed up to the fullest extent permitted by the applicable regulations. The renewal of the fellowship contract depends on the research fellow’s evaluation concerning the accomplishment of the work plan, the fulfillment of personal requirements for the fellowship renewal and the availability of funding in the project. The fellowship is planned to start in October or November of 2023.

MONTHLY MAINTENANCE ALLOWANCE The fellowship’s maintenance allowance is 930,98 € per month, according to the table of values of the grants awarded directly by FCT, I.P. in the Country. Further information at https://former.fct.pt/apoios/bolsas/valores.phtml.en. The fellowship will be paid monthly by bank transfer.

REQUIRED DOCUMENTS FOR APPLICATION Applications are to be submitted in English. Applications shall include the following documents: 1. Cover letter; 2. Curriculum Vitae including all the elements to access the admission requirements; 3. Master’s degree Certificate/Diploma, referring the final classification; 4. Proof of the enrolment in the required program or proof of meeting the requirements for the enrollment in the required program In case of not being possible to obtain the certificate mentioned in 3. until the due date of the application, the candidate may replace them by declarations of their responsibility with the corresponding content, submitted electronically and, in case of grant of the fellowship, send the official certificates to CUBE, before the contract being handled.

DEADLINES AND SUBMISSION OF APPLICATIONS Required documents should be sent by e-mail to catolica-lisbon-research@ucp.pt from September 19th to October 2nd, 2023 (until 5 pm Lisbon time) with the reference Subject: CUBE-7844-BI/5- #Candidate's name#.

Organisation

Organisation name
Universidade Católica Portuguesa - CATÓLICA-LISBON
Organisation Country
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Job Features

Job CategoryTeaching and scientific research

CUBE – Católica Lisbon Research Unit in Business and Economics at Católica Lisbon School of Business & Economics, Universidade Católica Portuguesa, is awarding a one Research Fellowship (...View more

Are you curious to develop smart, sustainable and secure network solutions for Internet of Things, and how this enables Digital Twining and Smart Industry? Eager to see whether we are indeed protecting the IoT devices we should care about most, such as, real-time control systems, or the ever-more-pervasive smart-home systems, and to further our understanding on the balance between controls and functionality involved? And the other way round: see what threats these ‘IoT devices‘ themselves pose to their environment?

If you see yourself making an impact in any of these areas – or you have other interesting Internet of Things topics to bring to the table –, you should consider joining our Department of Advanced Computing Sciences (DACS) as an Assistant Professor in Internet of Things. DACS is an international community of ~100 researchers at various stages of their career, embedded in the Faculty of Science and Engineering (FSE). Our department has more than 30 years’ experience with research and teaching in the fields of Artificial Intelligence, Computer Science and Applied Mathematics.

What are you going to do?

We are looking for a colleague to strengthen our research initiatives on emerging computing technologies to boost high-performance artificial intelligence and data processing in robotics, distributed, networked and embedded systems. Within that scope your focus area will be on Internet of Things for which you will bring in and develop valuable expertise. You will join our team that focusses on enabling smart cities, smart home applications, and smart industries. This team operates at Maastricht University in Maastricht and at the Brightlands Smart Service Campus in Heerlen.

As Assistant Professor, you will be active in acquiring research funding, in high-impact research, and support fellow junior researchers.

As our new colleague, you will contribute to DACS research. Our research activities span the entire spectrum from curiosity-driven research to responsible societal applications, often taking on an interdisciplinary character. Contributions to areas such as multi-agent systems, (medical) signal and image processing, FAIR principles, game theory, intelligent search techniques and affective computing are internationally recognized. What makes our research so interesting is that DACS maintains an industry network with over 80 private collaborators ranging from local SMEs to large multinationals. The department designs and develops data-driven solutions for a wide variety of business applications in sectors including transport and logistics, healthcare, and production and manufacturing. This why you can contribute to science and our society of tomorrow!

In addition to your research, you will contribute to our top-rated education. Our department offers one bachelor’s program and two master programs, all of which are nationally ranked among the top of their kind and involve Data Science and Artificial Intelligence. In September 2023, we will also launch a new bachelor in Computer Science. You will have an important voice in developing our education programs.

Requirements

Specific Requirements
Who are you? We seek a colleague who is passionate about research and who enjoys teaching. You feel at home in a strongly international and diverse community like ours. Furthermore, we are looking to welcome someone who fosters collaboration at all levels. Our ideal candidate has:
  • A PhD degree in Internet of Things, Computer Science, Electrical Engineering or a strongly related field;
  • Preferably 2 years working experience in an academic environment post-PhD;
  • A proven track record in research and teaching;
  • Experience with funding acquisition at national and European level;

Additional Information

Benefits
As an Assistant Professor at the Faculty of Science and Engineering, you will be employed by the most international university of the Netherlands, located in the beautiful city of Maastricht. In addition, we offer you:
  • Good employment conditions. The position is in grated in scale 13-14 according to the UFO profile Assistant Professor, function level 2-1 with corresponding salary ranging from €4.332 to €6.737 gross per month (based on a full-time employment of 38 hours per week). In addition to the monthly salary, an 8.0% holiday allowance and an 8.3% year-end bonus are applicable.
  • An employment contract for a period of 18 months with a scope of 1.0 FTE. If proven suitable, the employment contract will be converted into an indefinite contract.
  • As Family-friendly University, we offer flexible working hours and the possibility to work partly from home if the nature of your position allows it. You will receive a monthly commuting and internet allowance for this. If you work full-time, you will be entitled to 29 vacation days and 4 additional public holidays per year, namely carnival Monday, carnival Tuesday, Good Friday, and Liberation Day. If you choose to accumulate compensation hours, an additional 12 days will be added. Furthermore, you can personalize your employment conditions through a collective labor agreement (CAO) choice model.
  • As Maastricht University, we offer various other excellent secondary employment conditions. These include a good pension scheme with the ABP and the opportunity for UM employees to participate in company fitness and make use of the extensive sports facilities that we also offer to our students.
  • Applicants from outside The Netherlands may be eligible for the so-called 30% ruling, a tax cut for highly skilled migrants that applies for a maximum of five years. If you are moving to Maastricht from more than 40 kilometers away, you may qualify for a one-time reimbursement of your relocation costs
  • Last but certainly not least, we provide the space and facilities for your personal and professional development. We facilitate this by offering a wide range of training programs and supporting various well-established initiatives such as 'acknowledge and appreciate'.
The terms of employment at Maastricht University are largely set out in the Collective Bargaining Agreement of Dutch Universities. In addition, local provisions specific to UM apply. For more information, Click here
Selection process
Please send in the following documents:
  • Research statement;
  • Teaching statement;
  • CV;
  • List of publications;
  • Contact information (names, e-mail addresses, and phone number) of two persons willing to provide references.
Applications received by (end of day) Sunday, October 15 2023 will receive full consideration. Maastricht University is committed to promoting and nurturing a diverse and inclusive community. We believe that diversity in our staff and student population contributes to the quality of research and education at UM, and strive to enable this through inclusive policies and innovative projects led by teams of staff and students. We encourage you to apply for this position. Please note, the system cannot upload the following attachments (xyz.zip .htm .html).
Additional comments

If you have questions about this position, you can refer to:

Prof. Mark Winands (Professor in Machine Reasoning; Chair of Department of Advanced Computing Sciences) m.winands@maastrichtuniversity.nl

Job Features

Job CategoryTeaching and scientific research

Are you curious to develop smart, sustainable and secure network solutions for Internet of Things, and how this enables Digital Twining and Smart Industry? Eager to see whether we are indeed protecti...View more

Austria
Posted 1 year ago

Offer Description

Start date/duration

  • as soon as possible
  • for 4 years
 

Job profile:

In this position you are expected to write a dissertation (in railway superstructure topics, e.g. load distripution, stability, vibration mitigation) in a stimulating environment using the university's infrastructure. You will hold your own lectures, tutor students and participate in administration. 50% of the working time is reserved for the thesis. Very good skills of the German (technical) language (for teaching and research), both written and spoken (at least C1 desired).  

Application:

We are looking forward to receiving your online application. The full, legally binding call for application (in German) including the salary can be found here: https://lfuonline.uibk.ac.at/public/karriereportal.details?asg_id_in=13813 The University of Innsbruck is committed to raising the quota of female employees and therefore explicitly welcomes applications from qualified female scientists. In the case of female underrepresentation women with equal qualifications will be given priority. In accordance with Austrian disability laws qualified people with special requirements are expressly encouraged to apply for jobs. For more information please contact the trusted representative for scientists with a disability at the University of Innsbruck, Dr. Adolf Sandbichler.

Requirements

Additional Information

Benefits

What the University of Innsbruck offers:

From a company pension scheme, to flexible working hours and child care facilities the University of Innsbruck offers its employees a wide range of benefits which is being continuously extended. Along with interesting oppurtunities for the participation in job-related and personal further education courses, and the succesful compatibility of career and family, employees can benefit from a large range of courses offered by the University Sports Institute (USI), the language courses offered by the ISI, the University Library and take advantage of the various canteens offering reasonably priced food. A summary of the benefits for University employees can be found here: http://www.uibk.ac.at/universitaet/zusatzleistungen/
Additional comments

The University of Innsbruck as employer

Are you looking for a new challenge? The University of Innsbruck is a place of study, research and employment for more than 31.000 people. As one of the largest employers in Tyrol the University offers a varied and exciting field of activity for its employees from very diverse educational and professional backgrounds. The University explicitly welcomes diversity and is committed to the principle of equal opportunity. It is a certified family-friendly workplace and received the award 'Top workplace 2018' from the Austrian business magazine 'trend'.

Languages

At the University of Innsbruck researchers from all over the world come together. Depending on the individual scientific community the language used may be German, English or another (if unanimously decided). Internal communication is in German. Therefore a basic knowledge of German or the willingness to acquire such knowledge is essential.

Work Location(s)

Number of offers available
1
Company/Institute
Intelligent Transport Systems - Planning, Construction, Operation and Management Section
Country
Austria
City
Innsbruck
Postal Code
A-6020
Street
Technikerstraße 13

Job Features

Job CategoryTeaching and scientific research

Offer Description Start date/duration as soon as possible for 4 years   Job profile: In this position you are expected to write a dissertation (in railway superstructure topics, e.g. load distrip...View more

The CNIC is searching for a Senior Researcher who will lead and develop a research line in the field of cardiovascular research aligned with any of the main research areas of the center.

As group leader, the selected candidate will be responsible for the development of the research lines of the laboratory. Moreover, she/he will be expected to obtain extramural funding from the most competitive national and international sources to finance such projects, and to publish scientific results in international journals of the highest impact factor in the cardiovascular field, and/or general medicine field, and/or multidisciplinary sciences field. The selected candidate will supervise the work of all members of the group, including research and technical staff. Other tasks include the coordination and management work requested by CNIC leadership including participation in committees and helping in other needs that may arise.

Requirements

Research Field
Biological sciences » Other
Education Level
PhD or equivalent
Specific Requirements
Mandatory requirements:
  1. PhD in the field of Life Sciences (Biology, Chemistry, Medicine, etc.).
  2. At least 10 years of experience as Group Leader in a research center with international recognition in the cardiovascular field.
  3. A minimum of 6 scientific publications (original articles) as corresponding author (or co-corresponding author) in journals ranked in the first decile of their field in the last 5 years (e.g., since September 2018).
  4. Experience as Principal Investigator and/or Coordinator in research grants obtained from international* funding sources in the last 5 years. (*funder based outside Spain).
  5. Main topic of research aligned with one of the research programs of the CNIC (https://www.cnic.es/en/research-programs).

Additional Information

Benefits
We offer:
  • A research position in a consolidated Research Centre of international scientific relevance.
  • Access to state-of-the art infrastructures and advanced technologies.
  • Integration into an excellent scientific environment.
  • Immediate incorporation adaptable to the candidate circumstances
  • Permanent position in accordance with the Spanish labour law (Contrato de duración indefinida) and according to “Tasa de Reposición: Resolución de Hacienda del 21 de agosto del 2023. N/REF. 2304381”
Eligibility criteria
Valuable requirements:
  • C1. Scientific production: publications (original articles) as corresponding author (or co-corresponding author) in journals ranked as first decile in their fields in the previous 5 years (i.e. date of publication since September 2018). Only published papers (or available online ahead of print in the journal) will be evaluated. The CV must include the complete list of authors and the journal´s impact factor and ranking in the year of publication for each publication published since September 2018.
This criterion will be valued according to the number of papers. (30%)
  • C2. Fundraising (international): Projects obtained from international* funding sources as principal investigator or coordinator in the previous 5 years (i.e. active projects in September 2018 onwards).
*funder based outside Spain This criterion will be valued according to the relevance of the funding source, the amount granted, and the number of projects. The CV must include each project, indicating the role of the candidate in the grant, amount granted, period of funding, and funding agency. (20%)
  • C3. Fundraising (national): Projects obtained from national funding sources as principal investigator or coordinator in the previous 5 years (i.e. active projects in September 2018 onwards).
This criterion will be valued according to the relevance of the funding source, the amount granted, and the number of projects. The CV must include each project, indicating the role of the candidate in the grant, amount granted, period of funding, and funding agency. (10%)
  • C4. International recognition: Participation in international committees/boards, grant evaluation panels, invited talks in major international meetings, and editorial boards in the previous 5 years.
This criterion will be valued according to the relevance of the boards, role played in these, and number of activities. (10%)
  • C5. Training and mentoring: Experience in training and mentoring of young researchers (PhD students, postdoctoral researchers, MD trainees, etc), and participation in training courses in the previous 5 years.
This criterion will be valued according to the number of PhD thesis directed (defended in the evaluation period), number of postdoctoral fellows supervised with subsequent research position in other centers and the relevance of such positions (which should be indicated in the CV), and role in training courses. (5%)
  • C6. Impact on society: Translation of research discoveries to the clinics, invention of patents, relation with industry in the previous 5 years.
This criterion will be valued according to the relevance of research for society/patients, number and relevance of patents, and research interactions with industry. (10%)
  • C7. Cardiovascular focus: Cardiovascular nature of the papers published as corresponding author (or co-corresponding author) and of the projects as principal investigator in the previous 5 years.
This criterion will be evaluated as the weight of cardiovascular research in the overall scientific production and fundraising of the candidate. (10%)
  • C8. Underrepresentation of gender by category, in accordance with Action S1 of the 2021-2024 Equality Plan, positive action in calls for posts. (5%)
Selection process

The candidate with the highest score will be hired given the total score is higher than 85 points (see below Evaluation Criteria C1-C8).

Job Features

Job CategoryTeaching and scientific research

The CNIC is searching for a Senior Researcher who will lead and develop a research line in the field of cardiovascular research aligned with any of the main research areas of the center. As group lead...View more

Le laboratoire INSERM U1253 recrute un chercheur associé (avec 0 à 3 ans d'expérience post-doctorale) pour mener un projet de recherche financé par l'ANR (Agence Nationale de la Recherche) visant à développer des traceurs TEP pour l'α-synucléine. La protéine α-synucléine s'accumule et s'agrège dans le cerveau des patients atteints de la maladie de Parkinson, provoquant la mort des neurones dopaminergiques des voies striatonigrales. Être capable de surveiller la charge en α-synucléine chez les patients parkinsoniens permettrait un diagnostic et une stratification plus fins des patients pour i) mieux comprendre la progression de la maladie et la relation entre la charge en α-synucléine et les symptômes et ii)surveiller l’efficacité des nouvelles thérapies. Cependant, jusqu’à présent, il n’existe aucun radiotraceur TEP présentant une spécificité élevée pour l’α-synucléine, et la liaison à d’autres agrégats tels que la β-amyloïde est courante. L'objectif de ce projet est de cribler de nouvelles molécules in vitro pour établir leurs propriétés pharmacologiques à l'aide d'expériences de liaison sur des préparations de cultures cellulaires et des coupes de cerveau et, une fois qu'un candidat approprié aura été identifié, procéder à sa caractérisation et validation in vivo par PET- CT dans des modèles animaux. Le candidat idéal aurait des connaissances en pharmacologie, neurosciences et maladies neurodégénératives (idéalement maladie de Parkinson) et une expérience antérieure (doctorat ou post-doctorat) en i) culture cellulaire, ii)expériences de liaison in vitro et iii) imagerie in vivo (de préférence, mais non obligatoire, TEP et développement de traceurs).

ACTIVITÉS PRINCIPALES

  • Cultures cellulaires.
  • Préparation et coupe des tissus.
  • Réalisation d'expériences de liaison (compétition, saturation) in vitro sur des préparations de cultures cellulaires et du cerveau (coupe et/ou homogénats) avec de nouveaux ligands.
  • Interprétation des données in vitro pour sélectionner les meilleurs composés pour le radiomarquage.
  • Réalisation de scans PET-CT chez de petits animaux avec les composés sélectionnés.
  • Analyse des images et des données TEP.
  • Interprétation et préparation des données pour publication, préparation du manuscrit.

ACTIVITÉS PRINCIPALES

  • Manipulation des animaux.
  • Préparation des animaux pour les PET scans.
  • Expériences in vitro : immunohistochimie, histologie, Western blot.

UNITÉ INSERM U1253 DIRECTEUR : Dr Catherine Belzung

Equipe 3 : Imagerie moléculaire et US & analyse d'images

Exigences

Domaine de recherche
Sciences Biologiques
niveau d'éducation
Doctorat ou équivalent
Domaine de recherche
Sciences pharmacologiques
niveau d'éducation
Doctorat ou équivalent
Domaine de recherche
Neurosciences
niveau d'éducation
Doctorat ou équivalent
Compétences/qualifications
  • Excellente compréhension de la pharmacologie
  • Expérience antérieure dans la réalisation d'expériences de liaison.
  • Expérience en neuroimagerie (de préférence TEP, mais autres modalités acceptées)
Exigences particulières
Détenir une licence d'expérimentation animale et une expérience préalable en expérimentation animale serait un plus.
Langues
ANGLAIS
Niveau
Bien

Informations Complémentaires

Processus de sélection

Les candidats doivent envoyer un CV et une lettre de motivation à : Dr Hervé Boutin ( herve.boutin@inserm.fr ) ou Dr Sylvie Chalon ( sylvie.chalon@univ-tours.fr )

Contact pour tout renseignement complémentaire (nom, téléphone/mail) : Dr Hervé Boutin ( herve.boutin@inserm.fr ) ou Dr Sylvie Chalon ( sylvie.chalon@univ-tours.fr )

Job Features

Job CategoryTeaching and scientific research

Le laboratoire INSERM U1253 recrute un chercheur associé (avec 0 à 3 ans d’expérience post-doctorale) pour mener un projet de recherche financé par l’ANR (Agence Nationale de la Recher...View more

Thinking of doing your PhD in the Life Sciences? The International PhD Programme (IPP) Mainz is offering talented students the chance to work at the cutting edge of research. As an IPP PhD student, you will join a community of exceptional scientists working on diverse topics ranging from how organisms age or how our DNA is repaired, to how epigenetics regulates cellular identity or neural memory.

Activities and responsibilities:

In the field of “Ageing & Disease”, the research group of Björn Clausen offers the following PhD project:

Colorectal cancer (CRC) is a leading cause of cancer-related deaths among men and women worldwide, with increasing incidence rates, in particular in young people. CRC can arise sporadically or due to chronic inflammation, and both genetic disposition as well as environmental factors contribute to the development of CRC. Risk factors include age and lifestyle such as poor dietary habits, alcohol consumption, smoking, obesity, and lack of physical activity, and possibly viral infections. Patients with long-standing inflammatory bowel diseases exhibit a higher risk to develop colitis-associated colorectal cancer (CAC).

B cells are an important part of the immune cell infiltrate of tumors, and their contribution to tumor initiation, development, and immunosurveillance is complex with both pro- and anti-tumorigenic effects. Recent studies implicate a fundamental role of B cells in shaping anti-tumor responses through several mechanisms. While IgA+ plasma cells regulate bacterial populations in the gut lumen in steady state, plasma cell-derived tumor-specific IgG1 antibodies mediate cell cytotoxicity and phagocytosis of tumor cells. In addition, B cells present tumor-specific antigens via MHCI and MHCII to T cells inducing their anti-tumor effector function. B cells also regulate the immune response within the tumor microenvironment through the release of cytokines, such as IFN-g, IL-12, or IL-10. CRC patients show substantial alterations in their B cell compartment, with increasing numbers of IL-10 producing B cells in advanced tumors and metastases. CRC patients with tumors highly infiltrated by CD20+ B cells display significantly improved survival, which suggests an anti-tumor role of B cells. In line, B cells are closely associated with CD8+ cytotoxic T cells, which are important in antigen-specific immunity against tumors. Antibody-independent mechanisms such as antigen presentation, cytokine production, direct cytotoxicity, and indirect effects through modulation of other immune cells have been demonstrated to be of great importance. Thus, whether B cells promote or inhibit tumor growth depends on different variables, such as temporal and spatial settings, as well as on the composition of B cell subsets. Therefore, a phenotypical and functional characterization of B cells in CRC tumor initiation and progression is of great interest with a possible therapeutic benefit.

PhD project: The role of B cells in Colorectal Cancer Development and Progression

The molecular and cellular mechanisms underpinning inflammatory processes that promote epithelial transition to carcinogenesis are still only insufficiently characterized, and especially how B cells contribute to these processes. We started investigating the role of B cells in the inflammatory phase, and at later time points of tumor development/progression in the well-established animal model of inflammation-induced CRC (AOM/DSS). We could show that B cells exert an important role by using B cell-deficient mice (JHT mice), which were completely resistant to AOM/DSS-induced inflammation as well as CRC development. Further, we could show that B cell-specific secretion of the immunosuppressive cytokine IL-10 drives CAC development, whereas it does not affect the inflammatory phase of CAC development.

In this proposed project, we will further elucidate the role of B cells in CAC using the AOM/DSS model. We will perform a detailed in vivo and in vitro analysis of different transgenic animals, manipulating, for example, antibody secretion using mice that are not able to secrete antibodies (IgMi mice). We will further use mice that allow us to delete B cells at any desired time point of CRC development to investigate the temporal/spatial role of B cells in colon carcinogenesis (iDTRCD19-cre mice).

In addition, we will employ a non-inflammatory model of sporadic CRC since preliminary data also show a significant role of B cells in this tumor entity. Besides these animal models, we will perform different molecular methods, flow cytometric analysis, immunohistochemistry as well as single cell and bulk RNA sequencing from tumors as well as the tumor microenvironment. We will create organoids, if possible, also from human tissue samples.

Finally, we will translate our experimental findings to the clinic by using human CRC samples from patients with inflammation-induced CRC in comparison to patients suffering from sporadic CRC and investigate the contribution of B cells.

Of note, this project is jointly conducted by the Hövelmeyer and Clausen laboratories at the Institute for Molecular Medicine in Mainz, as funded by the established DFG CRC 1292.

If you are interested in this project, please select Clausen (Canc) as your group preference in the IPP application platform.

What we offer:

  • Exciting, interdisciplinary projects in a fully international environment, with English as our working language
  • Advanced training in scientific techniques and professional skills
  • Access to our state-of-the-art Core Facilities and their technical expertise
  • Fully funded positions with financing until the completion of your thesis
  • A lively community of more than 190 PhD students from 44 different countries

Requirements:

Are you an ambitious, young scientist looking to push the boundaries of science while interacting with colleagues from multiple disciplines and cultures? Then the IPP is your opportunity to give your scientific career a flying start!

All you need is:

  • Master or equivalent
  • Interactive personality & good command of English
  • 2 letters of reference

For more details on the projects offered and how to apply via our online form, please visit https://www.imb.de/phd

The deadline for applications is 8 November 2023. Interviews will take place at IMB in Mainz on 22-24 January 2024.

Starting date: 1 March 2024 – 1 August 2024

Job Features

Job CategoryDoctorat

Thinking of doing your PhD in the Life Sciences? The International PhD Programme (IPP) Mainz is offering talented students the chance to work at the cutting edge of research. As an IPP PhD student, ...View more

Thinking of doing your PhD in the Life Sciences? The International PhD Programme (IPP) Mainz is offering talented students the chance to work at the cutting edge of research. As an IPP PhD student, you will join a community of exceptional scientists working on diverse topics ranging from how organisms age or how our DNA is repaired, to how epigenetics regulates cellular identity or neural memory.

Activities and responsibilities:

In the field of “Ageing & Disease”, the research group of Björn Clausen offers the following PhD project:

The oral mucosa represents a barrier tissue to the environment where the balance of immunity and tolerance is vital, as it is constantly exposed to pathogens and harmless foreign antigens, including commensals. A breakdown of this balance leads to dysbiosis resulting in periodontitis, an infection-induced inflammatory disease characterized by irreversible destruction of the tooth-supporting tissues including loss of the underlying bone. Moreover, it is considered a risk factor for life-threatening conditions such as cardiovascular disease. Dendritic cells (DC), including Langerhans cells (LC), have the unique capacity to promote both tolerogenic and inflammatory immune responses. Hence, in order to design effective therapeutic strategies to treat periodontitis and reduce the risk of developing comorbidities, it is essential to understand how DC in the oral mucosa maintain immune homeostasis.

PhD project: E-cadherin and β-catenin signaling in dendritic cells for the maintenance of immune homeostasis in the oral mucosa

One pathway that plays a crucial role in DC homeostasis and tolerance induction is E-cadherin/β-catenin signaling. The cell adhesion molecule E-cadherin is only expressed by LC and we recently showed that it is involved in the 2-step process of their differentiation in the oral mucosa. Notably, to what extent E-cadherin/β-catenin signaling regulates LC/DC homeostasis and function in the oral mucosa is not known. In pilot experiments, we analyzed the oral mucosa of transgenic mice lacking E-cadherin in CD11c+ cells (CD11c-EcadDEL) and observed an altered LC subset distribution and a dramatically changed morphology with more rounded cell bodies and fewer dendrites compared to controls. In the proposed project a detailed in vivo and in vitro analysis of CD11c-EcadDEL and β-catenin deficient (CD11c-βcatDEL) mice will be performed. First, we will assess LC and DC homeostasis, activation and migration in the different oral tissues by high-dimensional flow cytometry as well as the impact of CD11c-specific E-cadherin or β-catenin deletion on other immune cell populations. Moreover, we detected oral dysbiosis in our CD11c-EcadDEL mice and therefore, a detailed taxonomic microbiota analysis will be performed in this project. Since persistent microbial dysbiosis results in inflammation and subsequently alveolar bone loss, we will analyze the oral tissues of CD11c-EcadDEL and CD11c-βcatDEL mice for T cell infiltration and inflammatory cytokines. Bone loss will be monitored by micro computed tomography (µCT) scans. Finally, in different mouse models of periodontitis (P. gingivalis- and ligature-induced periodontal disease) we will interrogate the impact of E-cadherin/β-catenin signaling on LC/DC during infection and inflammation. Applying single-cell RNA sequencing the molecular pathways affected by E-cadherin/ β-catenin signals in oral mucosal LC/DC will be deciphered. Our expected findings may thus have important implications for designing improved LC/DC-based strategies for the treatment of periodontal disease.

If you are interested in this project, please select Clausen (DC) as your group preference in the IPP application platform.

What we offer:

  • Exciting, interdisciplinary projects in a fully international environment, with English as our working language
  • Advanced training in scientific techniques and professional skills
  • Access to our state-of-the-art Core Facilities and their technical expertise
  • Fully funded positions with financing until the completion of your thesis
  • A lively community of more than 190 PhD students from 44 different countries

Requirements:

Are you an ambitious, young scientist looking to push the boundaries of science while interacting with colleagues from multiple disciplines and cultures? Then the IPP is your opportunity to give your scientific career a flying start!

All you need is:

  • Master or equivalent
  • Interactive personality & good command of English
  • 2 letters of reference

For more details on the projects offered and how to apply via our online form, please visit https://www.imb.de/phd

The deadline for applications is 8 November 2023. Interviews will take place at IMB in Mainz on 22-24 January 2024.

Starting date: 1 March 2024 – 1 August 2024

Job Features

Job CategoryDoctorat

Thinking of doing your PhD in the Life Sciences? The International PhD Programme (IPP) Mainz is offering talented students the chance to work at the cutting edge of research. As an IPP PhD student, ...View more

You will work with a team of researchers and developers from UPF. Martí Sánchez Fibla will be the scientific person in charge. You will have the opportunity to directly interact with the innovation line of the company but from the university and with a research focus.

You will be working in the project Matching Learning (red.es BMAT-UPF) in close collaboration with the company BMAT (en.wikipedia.org/wiki/BMAT_Music_Company). BMAT is a music company that uses artificial intelligence to index, monitor and report music usage and ownership data across TVs, radios, venues and digital platforms worldwide.

This offer gives the opportunity to work on a highly new and innovative field: the application of state of the art Natural Language Processing tools based on Deep Learning and Large Language Models (GPTx and open source versions of ChatGPT) to process (semi and unstructured) data.. The challenges that you will be addressing will be realistic and relevant for industry as they will be provided directly from BMAT.

These tasks are related to completion of the project by 30/05/2024. The concrete tasks to be accomplished are:

  • T1. Intelligent meta-data matching. Develop python software based on Deep Learning techniques (through Deep Neural Networks, DNNs as transformers networks, through the use of the so-called Embeddings) to resolve the matching problems of metadata that the company has identified. Datasets will be provided and different techniques will be implemented, tested and benchmarked.
  • T2. Develop specific methods for a specific use-case. Do specific training of DNNs to solve the metadata matching problems in a specific domain: for example the Music Production domain. Compare how a specific fine tuning of DNNs can solve the tasks better. Evaluate and benchmark results.

Dedication and working hours: Part time (30h/week)

Planned remuneration approx: 27.280,86 € gross / year

Main research field: Artificial Intelligence / Natural Language Processing

Project: Motor de reconciliación de entidades impulsado por IA para la industria de la música (Matching Learning)

Financing fund: CN08722 - BMAT LICENSING, S.L.U.-Martí Sánchez Fibla- Realización del proyecto consistente en aplicar los recientes resultados en investigación en Inteligencia Artificial del procesado del lenguaje aportados por UPF, a la gran cantidad y diversidad de datos en el dominio de producción musical de BMAT, the project ends on 30/05/2024.

Requirements

Research Field
Computer science
Education Level
Bachelor Degree or equivalent
Skills/Qualifications
We will value:
  • Experience in Natural Language Processing (NLP) programming techniques.
  • Knowledge of specific NLP libraries like Hugging Face transformers API.
  • The position has a research focus so we will value the ability to read, understand and be able to use code from research papers of the field. Example of papers that can be relevant: “Efficient Estimation of Word Representations in Vector Space”, Mikolov et al., 2013; “Attention is all you need”, Vaswani et al., 2017.
Specific Requirements
  • Engineer with an undergraduate degree (or equivalent) in Computer Science or related disciplines, with a Final Project related to the field.
  • Previous contact with the academic world either: having done a Master Thesis in a related topic or an internship in a research group or an internship in a company.
  • Proficiency in Python programming will be required and proven experience with deep learning in any of the libraries tensorflow / keras / pytorch.
  • Good English Level, reading and writing.
The expected start date is 10 Novembre 2023, the job is in Barcelona, and Nie and a work permit is required and in case of not having it, demonstrate being in a process of renewal of visa and having a residency in Barcelona one week previous to the start.

Additional Information

Eligibility criteria
The selection of the candidates will be made through evaluation of the curriculum and, where appropriate, with the carrying out a test and/or interview. Valuation will be as follows:
  • Academic background: 30 points.
  • Relevant research and/or professional experience: 50 points - Experience in Natural Language Processing. (NLP) programming technique.
  • Other merits: 20 points - Knowledge of specific NLP libraries like Hugging Face transformers API., The position has a research focus so we will value the ability to read, understand and be able to use code from research papers of the field. Example of papers that can be relevant: “Efficient Estimation of Word Representations in Vector Space”, Mikolov et al., 2013; “Attention is all you need”, Vaswani et al., 2017.
The minimum score to pass the selection process is 80 points. The candidate with the highest score in the selection process will be offered the job and in case of resignation, the position will be awarded to the next person in order of score obtained, as long as the established minimum score has been passed.
Additional comments

For more information about the call, how to apply, the list of those admitted and excluded, as well as the hiring proposal, check the website: https://www.upf.edu/web/etic/management

Job Features

Job CategoryTeaching and scientific research

You will work with a team of researchers and developers from UPF. Martí Sánchez Fibla will be the scientific person in charge. You will have the opportunity to directly interact with the innovation ...View more

Thinking of doing your PhD in the Life Sciences? The International PhD Programme (IPP) Mainz is offering talented students the chance to work at the cutting edge of research. As an IPP PhD student, you will join a community of exceptional scientists working on diverse topics ranging from how organisms age or how our DNA is repaired, to how epigenetics regulates cellular identity or neural memory.

Activities and responsibilities:

In the field of “Ageing & Disease”, the research group of Wolfram Ruf offers the following PhD project:

Bone marrow-resident hematopoietic stem and progenitor cells (HSPC) are the source of all mature blood cells and replenish the body needs continuously in homeostasis and challenges throughout the life of the host. Although hematopoietic stem cells (HSCs) are mainly quiescent, they reversibly switch to proliferation upon challenges, such as infection, bleeding, or circadian rhythm. HSCs become dysfunctional in aging by incompletely understood cues from the bone marrow environment. This results in imbalances in the differentiation of HSPC that results in more inflammation (myeloid skewing) and age-related pathologies. Interactions of HSPC with various cellular and soluble (growth factors, extracellular vesicles) components of the bone marrow microenvironment crucially regulate the developmental fate of HSPC and proteases of the coagulation system have been shown to contribute to both matrix remodeling and regulation of homeostasis or mobilization of HSPC (extravascular coagulation signaling). Mutation or deficiencies of components of the coagulation system have been implicated in the regulation of HSPC in aging mouse models.

PhD project: Coagulation receptors in aging

The aim of the project is to determine the contribution of extravascular coagulation and immune signaling mechanisms to unbalanced hematopoiesis in aging with a long-term goal to possibly identify rejuvenation strategies. The work of the PhD candidate(s) will include the analysis of recently identified different mouse models with accelerated aging phenotypes and apply state of the art single cell technologies to characterize HSPC phenotypes and function. Characterization of the bone marrow environment by proteomics (e.g. of extracellular vesicles) may also be required to identify underlying molecular mechanisms for altered HSPC output in aging. Theoretical and practical knowledge in molecular and cell biology and/or protein chemistry are expected for successful candidates. The candidate should have an interest in systems biology approaches and develop skills to apply bioinformatics on newly generated and available omics data sets.

If you are interested in this project, please select Ruf as your group preference in the IPP application platform.

What we offer:

  • Exciting, interdisciplinary projects in a fully international environment, with English as our working language
  • Advanced training in scientific techniques and professional skills
  • Access to our state-of-the-art Core Facilities and their technical expertise
  • Fully funded positions with financing until the completion of your thesis
  • A lively community of more than 190 PhD students from 44 different countries

Requirements:

Are you an ambitious, young scientist looking to push the boundaries of science while interacting with colleagues from multiple disciplines and cultures? Then the IPP is your opportunity to give your scientific career a flying start!

All you need is:

  • Master or equivalent
  • Interactive personality & good command of English
  • 2 letters of reference

For more details on the projects offered and how to apply via our online form, please visit https://www.imb.de/phd

The deadline for applications is 8 November 2023. Interviews will take place at IMB in Mainz on 22-24 January 2024.

Starting date: 1 March 2024 – 1 August 2024

Job Features

Job CategoryDoctorat

Thinking of doing your PhD in the Life Sciences? The International PhD Programme (IPP) Mainz is offering talented students the chance to work at the cutting edge of research. As an IPP PhD student, ...View more

The OPVStability Marie Skłodowska-Curie Actions Doctoral Network (MSCA-DN) is an interdisciplinary research training network of 10 beneficiary universities from 7 countries. It is funded under the “Excellent Science” cluster of the Horizon Europe program. OPVStability aims to develop the Doctoral Candidate’s scientific expertise to produce excellent research, and interdisciplinary collaboration with scientists from different fields ranging from Physics, Chemistry, Materials Science and Data Science.  The OPVStability Marie Skłodowska-Curie Actions Doctoral Network (MSCA-DN) is an interdisciplinary research training network of 10 beneficiary universities from 7 countries. It is funded under the “Excellent Science” cluster of the Horizon Europe program. OPVStability aims to develop the Doctoral Candidate’s scientific expertise to produce excellent research, and interdisciplinary collaboration with scientists from different fields ranging from Physics, Chemistry, Materials Science and Data Science.

Topic:  High-throughput screening of organic materials This PhD research will focus on: i) Developing high-throughput screening methods for organic photovoltaics. ii) Screening for power conversion efficiency and stability. iii) Evaluation of novel systems and processing parameter space. iv) Study of large datasets that will be employed to feed statistical tools and artificial intelligence models.

Roles and Responsibilities

The main part of your work will be carried out at Institute of Materials Science of Barcelona (ICMAB-CSIC) in Barcelona, Spain, in the group of Prof. Mariano Campoy Quiles, and secondment placements are planned to take place at University of Bayreuth (Germany, 2 months), the company InfinityPV (Denmark, 1 month), and Karlstad University (Sweden, 2 months).

The OPVStability project will fund the PhD salary for three years (typically length of a PhD in Spain) and would start as soon as possible, no later than 1st of March 2024.

Your PhD degree will be awarded by Universitat Autònoma de Barcelona (UAB) on the basis of successful completion of the research work and PhD studies. You will also be required to participate in the training activities and workshops organized by the OPVStability MSCA-DN at different partner institutions in Europe. As a Marie Skłodowska-Curie Actions fellow, you are also expected to contribute to the dissemination of your project’s result through public engagement and other scientific platforms.

Requirements

Research Field
Chemistry
Education Level
Master Degree or equivalent
Research Field
Physics
Education Level
Master Degree or equivalent
Skills/Qualifications
The ideal candidate  
  • The applicant should have completed at least four- or five-years education with a Master’s degree or Diploma from a recognized university in Chemistry, Physics, Materials Science or in a related field and should be eligible as graduate student at Universitat Autònoma de Barcelona (UAB, see https://www.uab.cat/en/phds/materials-science#seccio-inici for further info).
  • The applicant should show interest in conducting a research project independently and should enjoy working in an international, interdisciplinary environment.
  • At the time of recruitment, the applicant must not have resided (or carried out his/her main activity e.g. work, studies, etc.) in Spain, for more than 12 months in the last 3 years immediately prior to the recruitment date.
  • The applicant should demonstrate an excellent command of the English language at a proficient level (spoken and written).
  • Experience in solution processed semiconductors and their applications will be valuable. In addition to the experimental skills, experience on device simulation would be also favorably reviewed.  International experience during Master’s or research stage/visits will also be positively considered.
Languages
ENGLISH
Level
Excellent
Languages
SPANISH
Level
Basic

Additional Information

Benefits
We offer an annual gross salary of at least € 33k for a fulltime position. The Institute of Materials Science of Barcelona (ICMAB-CSIC) aims to increase the proportion of women and therefore qualified female applicants are explicitly encouraged to apply. ICMAB-CSIC actively promotes diversity and equal opportunities. Applicants are not to be discriminated against in personnel selection procedures on the grounds of gender, ethnicity, religion or ideology, age, sexual orientation (anti-discrimination).  People with disabilities and who have the relevant qualifications are expressly invited to apply.
Selection process
To apply for the position, kindly provide: (i) a letter of motivation including a 1-page statement of your research interests, relevant skills and experience; (ii) a CV including publication list, and copies of relevant certificates and (iii) names and contact details of three referees willing to write confidential letters of recommendation.  All materials should be attached as a single PDF file (max. size 5MB). For interested applicants, please submit your application to our job portal using this link: https://opvstability.breezy.hr/   The closing date for all applications is 2 weeks after the publishing date.
Additional comments
For further information about OPVStability and the Doctoral Candidate positions, you may contact our Project Manager, Dr. Julirose Kourist at opvstability@tugraz.at. For questions related to the project, you may contact Prof. Mariano Campoy Quiles at mcampoy@icmab.es.
Website for additional job details

Job Features

Job CategoryDoctorat

The OPVStability Marie Skłodowska-Curie Actions Doctoral Network (MSCA-DN) is an interdisciplinary research training network of 10 beneficiary universities from 7 countries. It is funded under the ...View more

Thinking of doing your PhD in the Life Sciences? The International PhD Programme (IPP) Mainz is offering talented students the chance to work at the cutting edge of research. As an IPP PhD student, you will join a community of exceptional scientists working on diverse topics ranging from how organisms age or how our DNA is repaired, to how epigenetics regulates cellular identity or neural memory.

Activities and responsibilities:

In the field of “Epigenetics & Nuclear Dynamics”, the research group of Sandra Schick offers the following PhD project:

Genomic DNA is highly compacted into chromatin in order to fit into the nucleus of a cell. The packaging further provides a regulatory layer for DNA accessibility and therefore all DNA-dependent processes, such as transcription, DNA repair or replication. ATP-dependent chromatin remodellers can modulate the accessibility by moving or evicting nucleosomes. One class of these remodellers are the BAF complexes, very large multi-protein complexes existing in many different configurations in human cells. Their importance is highlighted by the fact that mutations in genes coding for these complexes are found in more than 20% of all human cancers and frequently causative for developmental diseases, especially several neurodevelopmental disorders. The molecular consequences of these mutations are hardly known so far. Therefore, understanding the cell type-specific composition and function of these complexes in the development of different organs as well as the cellular changes caused by the mutation of a subunit is of great importance for the development of therapeutics against these common BAF-mutated diseases.

PhD Project: Gene regulation by chromatin remodellers during development and disease

BAF complexes control the accessibility of cell type-specific genomic gene regulatory regions and are therefore of great importance for developmental processes, cell fate transitions during differentiation and cell maintenance. To understand their physiological role during human developmental processes and unravel disease-associated molecular alterations caused by mutations in genes encoding subunits of these complexes, we will implement stem cell differentiation into organoids combined with molecular perturbation tools such as CRISPR/Cas9 and chemically induced protein degradation. This will allow us to model developmental diseases and unravel the physiological role of the subunits/ BAF complexes in human developmental processes. With the help of bulk and single-cell genomics, proteomics, molecular biology, screening and imaging approaches, we will then dissect the cellular and molecular consequences upon loss of selected BAF subunits. This will provide novel insights into these diseases as well as the function of the BAF complexes and their subunits in developmental processes.

We are therefore looking for a highly motivated PhD student who is experienced in the lab, enthusiastic about science especially with regard to developmental processes, gene regulation and epigenomics and has a strong interest in tackling scientific questions in an interdisciplinary way. Computational skills are an asset but not compulsory.

If you are interested in this project, please select Schick as your group preference in the IPP application platform.

What we offer:

  • Exciting, interdisciplinary projects in a fully international environment, with English as our working language
  • Advanced training in scientific techniques and professional skills
  • Access to our state-of-the-art Core Facilities and their technical expertise
  • Fully funded positions with financing until the completion of your thesis
  • A lively community of more than 190 PhD students from 44 different countries

Requirements:

Are you an ambitious, young scientist looking to push the boundaries of science while interacting with colleagues from multiple disciplines and cultures? Then the IPP is your opportunity to give your scientific career a flying start!

All you need is:

  • Master or equivalent
  • Interactive personality & good command of English
  • 2 letters of reference

For more details on the projects offered and how to apply via our online form, please visit https://www.imb.de/phd

The deadline for applications is 8 November 2023. Interviews will take place at IMB in Mainz on 22-24 January 2024.

Starting date: 1 March 2024 – 1 August 2024

Job Features

Job CategoryDoctorat

Thinking of doing your PhD in the Life Sciences? The International PhD Programme (IPP) Mainz is offering talented students the chance to work at the cutting edge of research. As an IPP PhD student, ...View more

Thinking of doing your PhD in the Life Sciences? The International PhD Programme (IPP) Mainz is offering talented students the chance to work at the cutting edge of research. As an IPP PhD student, you will join a community of exceptional scientists working on diverse topics ranging from how organisms age or how our DNA is repaired, to how epigenetics regulates cellular identity or neural memory.

Activities and responsibilities:

In the field of “RNA Biology”, the research group of Marie-Luise Winz offers the following PhD project:

Proteins are central to any living organism. To protect cells from dysfunctional and toxic, disease-causing proteins formed by aberrant translation, eukaryotic translation quality control pathways detect translation defects and remove aberrant protein products, together with associated faulty mRNA blueprints and sometimes faulty ribosomal components. Many of those pathways rely on the recognition of ribosome collisions. Much is still unknown about the molecular mechanisms underlying translation quality control, and how these interact with other cellular machineries and with organismal health and life cycle. These are research objects in my group. Besides reporter systems and polysome profiling techniques, we use sequencing-based methods, most prominently UV crosslinking and analysis of cDNA (CRAC), to study RNA-protein interactions, translation and RNA modification in the context of translation quality control. These techniques provide a unique toolbox to approach our key questions:

1:           Which molecular interactions underlie translation quality control triggering and how are different targets distinguished?

2:           How does translation quality control interact with cellular stress responsestranslation regulation and RNA modification?

3:           How does co-translational quality control work in neurons and does it change with ageing and disease?

4:           What is the role of translation quality control for RNA-based and RNA-targeted therapies?

With our RNA-centred research, we want to make fundamental contributions to the understanding of translation quality control and its links to age-related neurodegenerative diseases, to ultimately inform efforts to cure, prevent or delay the onset of such diseases.

PhD project: Option 1: New players in eukaryotic translation quality control

Our group has recently discovered a number of potential new players in translation quality control by collating published information from a range of different databases and studies. We are currently investigating the potential functions of several such players in budding yeast, to define in which processes these proteins are involved and what is their molecular mechanism, using, e.g., CRAC, as well as reporter-based analyses (Müller, Tollervey, and Winz, unpublished; Iyer and Winz, unpublished).

Our current efforts so far only cover a small number of potential candidates. In this project, further candidates will be identified from published data and will be screened by reporter systems, equally in budding yeast. Positively evaluated candidates will be further studied to reveal their role in translation quality control. In addition to evaluating candidates from published screens and databases, to reveal additional candidates, new, targeted screens will be explored, followed by similar screens and evaluations.

PhD project: Option 2: Translation quality control in gene-specific translation inhibition

General inhibitors of bacterial translation play an important role as antibiotics. On the other hand, in human translation, a handful of small molecules have recently been discovered that target biosynthesis of a specific protein by targeting either the mRNA or the nascent peptide. It is now well accepted that many unspecific translation inhibitors can cause ribosome collisions and thereby trigger translation quality control pathways.

In this project, we will investigate which role translation quality control plays in specific translation inhibition in mammalian cells.

If you are interested in one of these projects, please select Winz as your group preference in the IPP application platform.

What we offer:

  • Exciting, interdisciplinary projects in a fully international environment, with English as our working language
  • Advanced training in scientific techniques and professional skills
  • Access to our state-of-the-art Core Facilities and their technical expertise
  • Fully funded positions with financing until the completion of your thesis
  • A lively community of more than 190 PhD students from 44 different countries

Requirements:

Are you an ambitious, young scientist looking to push the boundaries of science while interacting with colleagues from multiple disciplines and cultures? Then the IPP is your opportunity to give your scientific career a flying start!

All you need is:

  • Master or equivalent
  • Interactive personality & good command of English
  • 2 letters of reference

For more details on the projects offered and how to apply via our online form, please visit https://www.imb.de/phd

The deadline for applications is 8 November 2023. Interviews will take place at IMB in Mainz on 22-24 January 2024.

Starting date: 1 March 2024 – 1 August 2024

Job Features

Job CategoryDoctorat

Thinking of doing your PhD in the Life Sciences? The International PhD Programme (IPP) Mainz is offering talented students the chance to work at the cutting edge of research. As an IPP PhD student, ...View more

Thinking of doing your PhD in the Life Sciences? The International PhD Programme (IPP) Mainz is offering talented students the chance to work at the cutting edge of research. As an IPP PhD student, you will join a community of exceptional scientists working on diverse topics ranging from how organisms age or how our DNA is repaired, to how epigenetics regulates cellular identity or neural memory.

Activities and responsibilities:

In the field of “Epigenetics & Nuclear Dynamics”, the research group of Stamatis Papathanasiou offers the following PhD project:

Proper division of the genomic material is fundamental for cell homeostasis. Although cells have developed a plethora of mechanisms to ensure error-free division, mistakes during mitosis are common in normal physiology and a hallmark in disease. Such mistakes give birth to dysbalanced, aneuploid genomes. A prominent manifestation of mitotic errors is the generation of abnormal nuclear structures, such as micronuclei and chromosome bridges, common features of nuclear atypia in cancer with major physiological significance. Micronuclei are miniature, additional nuclei that form when a chromosome lags during mitosis and then recruits its own nuclear envelope. These structures accumulate massive DNA damage and can lead to severe rearrangements by mechanisms that are now starting to be understood. Yet, we do not fully understand the effects of dysbalanced genomes on cellular function and how these abnormalities contribute to disease initiation and progression.

We recently discovered a new phenomenon of heritable chromatin and transcriptional defects mediated by micronuclei. These alterations are inherited after the micronuclei reincorporate into the normal nuclear environment of daughter cells and are strongly associated with long-lived DNA damage. This work showed that chromosomal instability is inherently coupled to variation in gene expression, which may impact tumor evolution and provided significant insight into the elusive mechanisms leading to non-genetic, cell-to-cell epigenetic variability observed in pathophysiology.

PhD project: Chromatin state dysregulation due to abnormal mitosis

Under what exact circumstances cell division errors can give birth to massive DNA lesions and other chromatin alterations, their inheritance in the progeny and their functional significance remain a mystery. The potential involvement of additional mitosis-mediated mechanisms – other than micronucleation – that initiate cascades of non-genetic alterations is also a black box.

We are excited to welcome a PhD candidate to attack these questions. We will combine cutting edge techniques, such as targeted chromosome manipulation and gene engineering, with the development of advanced systems to track mis-segregated chromosomes by live-cell imaging over multiple generations. We will identify additional sources of inherited abnormal nuclear structures, investigate their DNA damage/repair dynamics and determine the immediate and long-term effects on these nuclear bodies’ epigenome.

If you are interested in this project, please select Papathanasiou (CSD) as your group preference in the IPP application platform.

What we offer:

  • Exciting, interdisciplinary projects in a fully international environment, with English as our working language
  • Advanced training in scientific techniques and professional skills
  • Access to our state-of-the-art Core Facilities and their technical expertise
  • Fully funded positions with financing until the completion of your thesis
  • A lively community of more than 190 PhD students from 44 different countries

Requirements:

Are you an ambitious, young scientist looking to push the boundaries of science while interacting with colleagues from multiple disciplines and cultures? Then the IPP is your opportunity to give your scientific career a flying start!

All you need is:

  • Master or equivalent
  • Interactive personality & good command of English
  • 2 letters of reference

For more details on the projects offered and how to apply via our online form, please visit https://www.imb.de/phd

The deadline for applications is 8 November 2023. Interviews will take place at IMB in Mainz on 22-24 January 2024.

Starting date: 1 March 2024 – 1 August 2024

Job Features

Job CategoryDoctorat

Thinking of doing your PhD in the Life Sciences? The International PhD Programme (IPP) Mainz is offering talented students the chance to work at the cutting edge of research. As an IPP PhD student, ...View more

University of Cologne Faculty of Management, Economics and Social Science

Assistant Professorship in Investments (W1), no tenure track (f/m/d) (endowed by the Centre for Financial Research (CFR), Cologne)

The University of Cologne is one of the oldest and largest universities in Germany. With its six Faculties covering a broad spectrum of disciplines and its internationally outstanding research profile areas, it enjoys an excellent reputation for its academic achievements and high standards of undergraduate and graduate education. The position is based in the Faculty of Management, Economics and Social Sciences, which is consistently ranked among the top schools in research and teaching.

YOUR TASKS The successful candidate is expected to contribute to research and teaching in the Department of Finance with a strong focus on Investments, Asset Management, or related areas. Research should be targeted at top ranked international journals. The tasks of the professorship include training of students at all levels. The candidate should contribute to one of the faculty’s key research initiatives (https://wiso.uni-koeln.de/en/research/key-research-initiatives).

YOUR PROFILE We are seeking academics at an early career stage who have demonstrated their academic aptitude through outstanding research in their doctoral studies. Candidates for this position should have very good skills in empirical methods common in finance and should apply them to questions in Investments, Asset Management, or related areas. Publications in high-quality academic journals as well as teaching experience are desirable.

OUR OFFER The University of Cologne provides a stimulating academic environment with a wide range of career development opportunities as well as support services for dual career couples and family-friendly working conditions.

The professorship is endowed by the Centre for Financial Research, Cologne, and located in the Department of Finance. The successful candidate can draw on outstanding research facilities including a broad set of databases (https://wiso.uni-koeln.de/en/faculty/wisolibrary-and-campus-service/research-databases) and the international research network of the Centre for Financial Research (www.cfr-cologne.de). The professorship is endowed with an attractive research budget and a part time research and teaching assistant (0.75 E 13 TV-L). Administrative support is provided by the Office Manager of the Department of Finance.

The position (of a Juniorprofessorin / Juniorprofessor) is available as of 01. June 2024 (based on mutual agreement). Formal requirements are detailed in Section 36 of the Higher Education Act of North Rhine-Westphalia (Hochschulgesetz – HG NRW).

In the third year after entering into office, an interim evaluation is held. This serves as the basis for the decision as to whether an extension for a further three years will be granted to the candidate. W1 professorships comprise a teaching load of four hours per week (i.e., two hours per week is one 90-minute course per semester) in the first qualification phase and five hours per week in the second qualification phase.

The University of Cologne is committed to equal opportunities and diversity. Women are especially encouraged to apply and will be considered preferentially in accordance with the Equal Opportunities Act of North Rhine-Westphalia (Landesgleichstellungsgesetz – LGG NRW). We also expressly welcome applications from people with disabilities / special needs or of equal status.

Please submit your application (without a photo) via the University of Cologne’s Academic Job Portal (https://professorships.uni-koeln.de) by 04.10.2023. Your application should be addressed to the Dean of the Faculty of Management, Economics and Social Science. It should consist of the following documents (in English language): cover letter, curriculum vitae including a list of publications and current research projects. If available, the most important publications or working papers, and teaching evaluations should be added as well. For further information, please contact Prof. Dr. Alexander Kempf (kempf@wiso.uni-koeln.de).

Job Features

Job CategoryTeaching and scientific research

University of Cologne Faculty of Management, Economics and Social Science Assistant Professorship in Investments (W1), no tenure track (f/m/d) (endowed by the Centre for Financial Research (CFR), Colo...View more

he International Max Planck Research School for Elementary Processes in Physical Chemistry (IMPRS-EPPC) at the Fritz Haber Institute of the Max Planck Society offers

5 PhD Positions in Physical Chemistry

The Fritz Haber Institute (FHI) in Berlin-Dahlem is one of the oldest and renowned research institutes within the Max Planck Society (MPG), Germany's most successful scientific organization for fundamental research. At the FHI, researchers from all over the world are engaged in basic research in the field of chemical physics at interfaces and surfaces, catalysis research and molecular physics.

The graduate school IMPRS-EPPC in Berlin is offering 5 PhD positions for research projects to be carried out with any of the participating research groups at the FHI, the Freie Universität Berlin, Humboldt-Universität zu Berlin, Technische Universität Berlin, and Universität Potsdam. The positions are linked to membership in the IMPRS-EPPC, and will be co-funded between the IMPRS-EPPC and the respective research groups. The IMPRS-EPPC is a graduate school funded by the MPG and hosted at the FHI in Berlin. The research within the School focuses on understanding the elementary process steps in physical chemistry problems, ultimately leading to functionality, ranging from single molecules chemistry on surfaces or in the gas phase to ultrafast surface dynamics and complex catalyst performance. All departments of the FHI as well as expert groups from physics and chemistry of all Berlin and Potsdam universities channel their respective efforts under the roof of the IMPRS-EPPC. For details see: https://www.fhi.mpg.de/imprs/research

Research Projects:

Candidates should propose a specific research project in Physical Chemistry and related fields, to be carried out with any of the participating research groups, see: https://www.fhi.mpg.de/imprs/PIs

Your application:

Applications will be accepted only through the Online Application form. The application deadline is Oct 31 2023. Highly motivated applicants should hold an excellent Master’s degree or equivalent in physics, chemistry, material science or related fields. For details of the application requirements please see: https://www.fhi.mpg.de/imprs/application We thank all applicants for their interest; however, only those individuals selected for an interview will be contacted.

Funding:

The position is initially limited to three years (extension possible) with a starting salary corresponding to a 66,67% TVöD/E13, Level 1, position. The positions will be co-funded between the IMPRS-EPPC (1st year) and the respective research group (remainder of the contract).

For more information please visit our website at https:// fhi.mpg.de/imprs or contact us: IMPRS-EPPC, Fritz-Haber-Institut der Max-Planck-Gesellschaft Faradayweg 4-6, 14195 Berlin, Germany e-mail: imprs@fritz-haber-institut.de Phone: +49-30-8413-5102

The Max Planck Society is committed to increasing the number of individuals with disabilities in its workforce and therefore encourages applications from such qualified individuals. Furthermore, the Max Planck Society seeks to increase gender diversity in research and therefore explicitly encourages women and non-binary people to apply.

Job Features

Job CategoryTeaching and scientific research

he International Max Planck Research School for Elementary Processes in Physical Chemistry (IMPRS-EPPC) at the Fritz Haber Institute of the Max Planck Society offers 5 PhD Positions in Physical Chemis...View more