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The laboratory of Dr. Roger Greenberg within the University of Pennsylvania Perelman School of Medicine is seeking postdoctoral researchers to investigate fundamental mechanisms that impact genome integrity. Our group has pioneered approaches to dynamically visualize the molecular events responsible for homologous recombination DNA repair in mammalian cells. These approaches and other methodologies that harness proteomic and CRISPR-Cas9 screening will be used to interrogate chromatin directed DNA repair mechanisms by BRCA1 and BRCA2 and their relationships to cancer eitiology and therapeutic response.
We are looking to appoint accomplished Postdoctoral Researchers in these areas. Candidates will have a PhD and/or MD in Biochemistry and Cell and Molecular Biology and an extensive publication record.
For details on our group, please visit our lab website at: https://www.med.upenn.edu/greenberglab/
Dr. Greenberg’s faculty site: http://www.med.upenn.edu/apps/faculty/index.php/p8145566
Application Instructions
Please submit your CV and a cover letter outlining your research interests, career goals and the names of up to three referees to Dr. Roger Greenberg at rogergr@pennmedicine.upenn.edu
Relevant Publications
Verma P, Zhou Y, Cao Z, Deraska PV, Deb M, Arai E, Li W, Shao Y, Li Y, Puentes L, Patankar S, Mach RH, Faryabi RB, Shi Y*, and Greenberg RA*. ALC1 links chromatin accessibility to PARP inhibitor response in homologous recombination deficient cells. Nat Cell Biol. 2021 Feb;23(2):160-171.
Harding SM, Benci JL, Irianto J, Discher DE, Minn AJ, and Greenberg RA. Mitotic progression following DNA damage enables pattern recognition within micronuclei, Nature 23:466-470, 2017
Dilley RL, Verma P, Cho NW, Winters HD, Wondisford AR, and Greenberg RA. Break Induced Telomere Synthesis Underlies Homology Directed Telomere Maintenance. Nature 539(7627):54-58, 2016.
Cho NW, Dilley RL, Lampson MA, Greenberg RA: Interchromosomal Homology Searches Drive Directional ALT Telomere Movement and Synapsis. Cell 159(1): 108-21, September 2014.
Tang J, Cho NW, Cui G, Manion EM, Shanbhag NM, Botuyan MV, Mer G, Greenberg RA: Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination. Nat Struct Mol Biol 20(3): 317-25, March 2013
